CAJ | 학술논문

目的观察肾移植受者应用麦考酚钠肠溶片(EC-MPS)和吗替麦考酚酯(MMF)后的骨髓抑制作用.方法自2008年1月至2012年12月底,102例肾移植受者用随机数法分配入组,EC-MPS组和MMF组各51例,两组受者的免疫抑制方案为环孢素A+EC-MPS(或MMF)+泼尼松,观察两组受者治疗后骨髓抑制情况,并进行疗效评定.结果 EC-MPS组受者血红蛋白的抑制作用强于MMF组(P=0.0454),MMF组受者血小板抑制作用强于EC-MPS组(P =0.001 6),EC-MPS组和MMF组受者白细胞的抑制作用的差异无统计学意义(P=0.167 4).结论 EC-MPS和MMF在肾移植受者骨髓抑制方面的影响有一定差异,应结合患者具体情况进行选择.
목적 관찰신이식수자응용맥고분납장용편(EC-MPS)화마체맥고분지(MMF)후적골수억제작용.방법 자2008년1월지2012년12월저,102례신이식수자용수궤수법분배입조,EC-MPS조화MMF조각51례,량조수자적면역억제방안위배포소A+EC-MPS(혹MMF)+발니송,관찰량조수자치료후골수억제정황,병진행료효평정.결과 EC-MPS조수자혈홍단백적억제작용강우MMF조(P=0.0454),MMF조수자혈소판억제작용강우EC-MPS조(P =0.001 6),EC-MPS조화MMF조수자백세포적억제작용적차이무통계학의의(P=0.167 4).결론 EC-MPS화MMF재신이식수자골수억제방면적영향유일정차이,응결합환자구체정황진행선택.
Objective To observe the bone marrow suppression of kidney transplant recipients after using mycophenolate sodium enteric-coated tablets (EC-MPS) versus mycophenolate mofetil (MMF).Method From January 2008 to the end of December 2012,102 cases of kidney transplant recipients were assigned into groups by random number method.Both of EC-MPS and MMF groups had 51 cases,and the immunosuppressive regimen was composed of cyclosporine A + EC-MPS (or MMF) + prednisone.The bone marrow suppression after application of two therapeutic regimens was observed,and the therapeutic effect was evaluated.Result EC-MPS group recipients had stronger hemoglobin inhibition than MMF group (P =0.045 4).The platelet functions in MMF group were inhibited more significantly than EC-MPS group (P =0.001 6).There was no statistically significant difference between EC-MPS and MMF group in leukocyte inhibition (P =0.167 4).Conclusion EC-MPS and MMF have some differences in bone marrow suppression of kidney transplant recipients,and for some patients the particular case should be concerned before making a choice.