CAJ | 학술논문

目的探讨不同全段甲状旁腺激素(intact parathyroid hormone,iPTH)水平对维持性血液透析(maintenance hemodialysis,MHD)患者临床指标的影响,并进行相关因素分析.方法选取HD患者共93例,测定iPTH及血生化指标,根据血iPTH水平分为A组iPTH＜150pg/ml,B组iPTH 150～300 pg/ml,C组iPTH＞300 pg/ml,比较3组年龄、糖尿病患病率、透析龄、体质量、体质量指数及血生化等临床指标,采用多元线性回归分析血iPTH与年龄、性别、糖尿病、透析龄、血校正钙、血磷、血碱性磷酸酶的相关性. 结果 A组相比,B、C组的年龄、肌酐和血磷水平均显著升高(P＜0.05)；A组的糖尿病患病率最高,B组和C组依次减少,差异有统计学意义(x2=11.393,P=0.03)；3组的iPTH、透析龄、血校正钙及ALP水平相比,差异有统计学意义(F=81.619,28.589,6.129,7.384;P=0.000,0.000,0.042,0.025),C组最高,其中B组与A组的iPTH及透析龄依次降低；多元线性回归分析表明,iPTH的平方根即Sqrt (iPTH)与透析龄(回归系数0.102)及血磷(回归系数3.077)成正相关,与糖尿病(回归系数-1.294)成负相关. 结论iPTH水平可影响MHD患者的预后；iPTH与透析龄、血磷呈正相关,与糖尿病呈负相关.
목적 탐토불동전단갑상방선격소(intact parathyroid hormone,iPTH)수평대유지성혈액투석(maintenance hemodialysis,MHD)환자림상지표적영향,병진행상관인소분석.방법 선취HD환자공93례,측정iPTH급혈생화지표,근거혈iPTH수평분위A조iPTH＜150pg/ml,B조iPTH 150～300 pg/ml,C조iPTH＞300 pg/ml,비교3조년령、당뇨병환병솔、투석령、체질량、체질량지수급혈생화등림상지표,채용다원선성회귀분석혈iPTH여년령、성별、당뇨병、투석령、혈교정개、혈린、혈감성린산매적상관성. 결과 A조상비,B、C조적년령、기항화혈린수평균현저승고(P＜0.05)；A조적당뇨병환병솔최고,B조화C조의차감소,차이유통계학의의(x2=11.393,P=0.03)；3조적iPTH、투석령、혈교정개급ALP수평상비,차이유통계학의의(F=81.619,28.589,6.129,7.384;P=0.000,0.000,0.042,0.025),C조최고,기중B조여A조적iPTH급투석령의차강저；다원선성회귀분석표명,iPTH적평방근즉Sqrt (iPTH)여투석령(회귀계수0.102)급혈린(회귀계수3.077)성정상관,여당뇨병(회귀계수-1.294)성부상관. 결론iPTH수평가영향MHD환자적예후；iPTH여투석령、혈린정정상관,여당뇨병정부상관.