CAJ | 학술논문

目的探讨兔鼻内镜下泪囊鼻腔吻合术中应用透明质酸酯(美乐胶Hyaff)作吻合口处填压物,对创面修复的影响.方法 24只兔行鼻内窥镜下泪囊鼻腔吻合术,随机分3组分别使用透明质酸酯、明胶海绵和凡士林纱条填压吻合口.2只兔做正常对照.双盲法观察各组术后临床变化,术后吻合口区的病理变化.结果术后3～5d美乐胶组临床局部反应较轻,病理炎症反应较轻；7d上皮覆盖创面,美乐胶全部溶解；10 d时上皮仍为复层,溶解的美乐胶部分吸收.结论应用透明质酸酯能减轻鼻内镜术后泪囊鼻腔吻合术术后泪囊黏膜的炎症反应,促进愈合,并自行溶解逐渐吸收.
목적 탐토토비내경하루낭비강문합술중응용투명질산지(미악효Hyaff)작문합구처전압물,대창면수복적영향.방법 24지토행비내규경하루낭비강문합술,수궤분3조분별사용투명질산지、명효해면화범사림사조전압문합구.2지토주정상대조.쌍맹법관찰각조술후림상변화,술후문합구구적병리변화.결과 술후3～5d미악효조림상국부반응교경,병리염증반응교경；7d상피복개창면,미악효전부용해；10 d시상피잉위복층,용해적미악효부분흡수.결론 응용투명질산지능감경비내경술후루낭비강문합술술후루낭점막적염증반응,촉진유합,병자행용해축점흡수.
Objective To investigate the pathological changes in the post-operative lacrimal sac mucosa by intranasal endoscopic dacryocystorhinostomy with hyaluronate (HYAFF,MeroGel) stuffing.Methods 24 rabbits received nasal endoscopic dacryocystorhinostomy were randomly divided into 3 groups.The hyaluronate,gelatin sponge and Vaseline gauze were used respectively for stuffing anastomosis.And two rabbits were normal control.The clinical signs and lacrimal sac mucosa pathological changes were observed in each group by double-blind.Results 3-5 days after operation,clinical reaction and pathological inflammatory reaction were mild in hyaluronate group; In this group,we observed that the hyaluronate dissolved and the anastomotic was covered by epithelia 7 days after operation.The dissolved hyaluronate was absorbed partly 10 days after operation.Conclusion The hyaluronate can reduce the lacrimal sac mucosal inflammation after nasal endoscopic dacryocystorhinostomy,promote incision healing,and dissolve itself gradually.