中国卫生经济
中國衛生經濟
중국위생경제
CHINESE HEALTH ECONOMICS
2013年
7期
59-61
,共3页
乙型病毒性肝炎%免疫策略%决策树模型%Markov模型%成本效果分析
乙型病毒性肝炎%免疫策略%決策樹模型%Markov模型%成本效果分析
을형병독성간염%면역책략%결책수모형%Markov모형%성본효과분석
hepatitis B immunization strategy%decision-tree model%Markov model%cost-effective analysis
目的：优化深圳市新生儿乙肝免疫预防策略。方法：通过决策树和Markov模型的建立，模拟我市不同乙肝免疫预防策略下2010年新生儿队列感染乙肝病毒及转归，结合我市的参数，运用成本-效果分析评价长期效果。结果：通过现行策略，筛查孕妇HBsAg并给予阳性孕妇的新生儿乙肝疫苗联合HBIG的免疫预防不仅能避免更多的新感染、肝癌和死亡病例的发生，而且获得更多的寿命年和QALYs。从社会角度分析，较现行策略节省40000000元。结论：建议深圳政府修改现行新生儿乙肝免疫预防策略，从而获得更大的经济效益和社会效益。
目的：優化深圳市新生兒乙肝免疫預防策略。方法：通過決策樹和Markov模型的建立，模擬我市不同乙肝免疫預防策略下2010年新生兒隊列感染乙肝病毒及轉歸，結閤我市的參數，運用成本-效果分析評價長期效果。結果：通過現行策略，篩查孕婦HBsAg併給予暘性孕婦的新生兒乙肝疫苗聯閤HBIG的免疫預防不僅能避免更多的新感染、肝癌和死亡病例的髮生，而且穫得更多的壽命年和QALYs。從社會角度分析，較現行策略節省40000000元。結論：建議深圳政府脩改現行新生兒乙肝免疫預防策略，從而穫得更大的經濟效益和社會效益。
목적：우화심수시신생인을간면역예방책략。방법：통과결책수화Markov모형적건립，모의아시불동을간면역예방책략하2010년신생인대렬감염을간병독급전귀，결합아시적삼수，운용성본-효과분석평개장기효과。결과：통과현행책략，사사잉부HBsAg병급여양성잉부적신생인을간역묘연합HBIG적면역예방불부능피면경다적신감염、간암화사망병례적발생，이차획득경다적수명년화QALYs。종사회각도분석，교현행책략절성40000000원。결론：건의심수정부수개현행신생인을간면역예방책략，종이획득경대적경제효익화사회효익。
Objective: To optimize the Shenzhen universal infant hepatitis B immunization method. Methods: To analyze the long effectiveness of different immunization strategies and disease transition after hepatitis B virus infection by using cost-effectiveness method through decision-tree and Markov models among the Shenzhen newborns cohort in 2010 based on the local parameters. Results:Through the current strategies, the program of screening all pregnant women for HBsAg and vaccinating newborns of single-positive mothers combing with HBIG and vaccine would not only prevent more new cases, hepatic carcinoma and related deaths; but also gain more living years and QALYs. From the social prospect, it will save about RMB 40 million compared with the current program. Conclusion: It is suggested that Shenzhen Government should amend the current universal infant hepatitis B immunization program to gain more economic and social benefits.
