CAJ | 학술논문

瘦素系统在肺部炎症反应、癌症发生发展等过程中发挥重要作用，但是其在肿瘤微环境中的作用机理、对肺癌的诊断价值仍不明晰。本文就瘦素系统与非小细胞肺癌之间的关系，从瘦素及其受体在循环和肿瘤组织中的表达变化、瘦素信号转导通路、瘦素与调节性T细胞的相互作用和瘦素及其受体的基因多态性等方面进行叙述，以期为非小细胞肺癌的诊治提供新方法。
수소계통재폐부염증반응、암증발생발전등과정중발휘중요작용，단시기재종류미배경중적작용궤리、대폐암적진단개치잉불명석。본문취수소계통여비소세포폐암지간적관계，종수소급기수체재순배화종류조직중적표체변화、수소신호전도통로、수소여조절성T세포적상호작용화수소급기수체적기인다태성등방면진행서술，이기위비소세포폐암적진치제공신방법。
Leptin system plays an important role in lung inlfammation and tumorigenesis, but the precise function in the tumormicrovironment and the prognosis value of the leptin system in lung cancer have not been fully elucidated. hTis re-view will focus on the relationship between leptin system and non-small cell lung cancer (NSCLC), in which special attentions will be paid on the expression of leption and its receptor (LepR) in peripheral blood and tumor tissues, leptin-related signal transduction pathways, the interaction between leption and regulatory T cells (Treg) and the gene polymorphisms of leptin and leptin receptor, and possibly provide new strategies for diagnosis and treatment of NSCLC.