CAJ | 학술논문

目的观察促红细胞生成素(EPO)治疗慢性心力衰竭合并贫血时的疗效及毒副作用.方法入选81例伴有贫血的慢性充血性心力衰竭(CHF)患者,随机分为治疗组(n=40例)和对照组(n=41例);对照组给予心力衰竭的血管紧张素转换酶抑制剂、地高辛、利尿剂、β阻滞剂等药物口服治疗;治疗组给予心力衰竭的常规治疗的基础上同时给予皮下注射EPO,疗程1年.对两组临床结果以及不良反应进行比较分析.结果两组治疗前后比较LVEF、心功能分级、六分钟步行试验、Hb和BNP比较差异有统计学意义(P＜0.05);两组治疗后观察指标比较差异有统计学意义(P＜0.05);两组治疗副作用比较差异无统计学意义(P＞0.05).结论 EPO能改善慢性心力衰竭合并贫血患者心功能指标、提高运动耐量,无明显毒副作用.
목적 관찰촉홍세포생성소(EPO)치료만성심력쇠갈합병빈혈시적료효급독부작용.방법 입선81례반유빈혈적만성충혈성심력쇠갈(CHF)환자,수궤분위치료조(n=40례)화대조조(n=41례);대조조급여심력쇠갈적혈관긴장소전환매억제제、지고신、이뇨제、β조체제등약물구복치료;치료조급여심력쇠갈적상규치료적기출상동시급여피하주사EPO,료정1년.대량조림상결과이급불량반응진행비교분석.결과 량조치료전후비교LVEF、심공능분급、륙분종보행시험、Hb화BNP비교차이유통계학의의(P＜0.05);량조치료후관찰지표비교차이유통계학의의(P＜0.05);량조치료부작용비교차이무통계학의의(P＞0.05).결론 EPO능개선만성심력쇠갈합병빈혈환자심공능지표、제고운동내량,무명현독부작용.
Objective To observe the clinical effect and side effects of erythropoietin (EPO) for treating chronic heart failure (CHF) patients with anemia.Methods 81 patients with CHF and anemia were randomly divided into the treatment group (n=40) and the control group (n=41); patients in the control group were given oral treatment of angiotensin converting enzyme inhibitors,digoxin,diuretics,[3 blocker.Patients in treatment group were given subcutaneous injection of EPO on the basis of the treatment for the control group.The clinical results and side effects of the two groups were comparatively analyzed.The course of treatment was 1 year.Results In the two groups,the LVEF,cardiac function,6-min-walking distance,hemoglobin and BNP after treatment were significantly improved,compared with those before treatment (P＜O.05).The results of the treatment group were significantly better than those of the control group (P＜0.05); and the side effects had no obvious difference between the two groups (P＞0.05).Conclusions EPO can improve the heart function indexes in patients with CHF and anemia,and can increase exercise tolerance,but without obvious side effects.