河南大学学报(医学版)
河南大學學報(醫學版)
하남대학학보(의학판)
JOURNAL OF HENAN UNIVERSITY (MEDICAL SCIENCE)
2014年
2期
145-149
,共5页
何敏%陈文武%成克定%姬新颖
何敏%陳文武%成剋定%姬新穎
하민%진문무%성극정%희신영
克雅二氏病%朊粒%实时震动诱导转化%诊断
剋雅二氏病%朊粒%實時震動誘導轉化%診斷
극아이씨병%원립%실시진동유도전화%진단
Creutzfeldt Jakob disease (CJD)%prion%realtime quaking induced conversion (RTQuIC)%prion disease diagnosis
克雅二氏病(Creutzfeldt-Jakob disease ,CJD)是朊粒(prion)类疾病在人类中最常见的病种,与其他常见的传染病不同的是,这个疾病不是由类似于含有基因的病毒或细菌的病原造成的疾病,而是由变构蛋白朊粒直接造成的疾病。尽管如此,它的公共健康的意义很大。因为朊粒在常规消毒情况下是不被灭活的。这类患者的朊粒会通过输血、手术或其他途径把病原传给他人,加上疾病发病的潜伏期长,很难马上被发现,给临床诊断造成很大困难。目前诊断主要限于临床表现及晚期的影像检查和组织学检查,特异性也比较低。早期和主动的、特异性的诊断方法一直是此领域的热点和亟待攻克的难题。近年来,克雅二氏病的研究和诊断有很大进展,因此,对目前国内外关于克雅二氏病的研究和诊断作一综述,特别是目前在世界少数国家出现的Real-time quaking-induced conver-sion (简称RT-QuIC ,此处翻译为“实时震动诱导转化”)作了详细介绍。
剋雅二氏病(Creutzfeldt-Jakob disease ,CJD)是朊粒(prion)類疾病在人類中最常見的病種,與其他常見的傳染病不同的是,這箇疾病不是由類似于含有基因的病毒或細菌的病原造成的疾病,而是由變構蛋白朊粒直接造成的疾病。儘管如此,它的公共健康的意義很大。因為朊粒在常規消毒情況下是不被滅活的。這類患者的朊粒會通過輸血、手術或其他途徑把病原傳給他人,加上疾病髮病的潛伏期長,很難馬上被髮現,給臨床診斷造成很大睏難。目前診斷主要限于臨床錶現及晚期的影像檢查和組織學檢查,特異性也比較低。早期和主動的、特異性的診斷方法一直是此領域的熱點和亟待攻剋的難題。近年來,剋雅二氏病的研究和診斷有很大進展,因此,對目前國內外關于剋雅二氏病的研究和診斷作一綜述,特彆是目前在世界少數國傢齣現的Real-time quaking-induced conver-sion (簡稱RT-QuIC ,此處翻譯為“實時震動誘導轉化”)作瞭詳細介紹。
극아이씨병(Creutzfeldt-Jakob disease ,CJD)시원립(prion)류질병재인류중최상견적병충,여기타상견적전염병불동적시,저개질병불시유유사우함유기인적병독혹세균적병원조성적질병,이시유변구단백원립직접조성적질병。진관여차,타적공공건강적의의흔대。인위원립재상규소독정황하시불피멸활적。저류환자적원립회통과수혈、수술혹기타도경파병원전급타인,가상질병발병적잠복기장,흔난마상피발현,급림상진단조성흔대곤난。목전진단주요한우림상표현급만기적영상검사화조직학검사,특이성야비교저。조기화주동적、특이성적진단방법일직시차영역적열점화극대공극적난제。근년래,극아이씨병적연구화진단유흔대진전,인차,대목전국내외관우극아이씨병적연구화진단작일종술,특별시목전재세계소수국가출현적Real-time quaking-induced conver-sion (간칭RT-QuIC ,차처번역위“실시진동유도전화”)작료상세개소。
Creutzfeldt Jakob disease (CJD) is the most common type of disease caused by prion .Different from other type of infectious diseases , this disease is caused by pathogens that contain genetic elements , such as viruses or bacteria . It is caused directly by a deformed protein called prion . Even so , the disease has important impact in public health , since prion can?t be destroyed in routine sterilization procedures . The prion from CJD patients can be transferred through blood transfusion , surgery , and other approaches . The disease has a long latent phase , and is hard to be identified . This causes a big problem in clinical diagnosis . The current diagnosis involves clinical signs , imaging , and histology with low specificity . Early and active diagnosis with high specificity is urgently needed . There are some big developments in the diagnosis of CJD in recent years . This paper summarizes the progress in this area domestically and internationally , especially the recently developed real time quaking induced conversion ( RTQuIC) in details .