CAJ | 학술논문

目的：研究血清中同型半胱氨酸（Hcy）水平与青壮年卒中后抑郁的相关性。方法选2011年9月至2013年11月门诊诊治的80例18～45岁脑卒中患者（发病≥3周）为研究对象，其中35例卒中后抑郁患者为A组，另45例卒中后未发生抑郁者为B组，35例健康体检者为对照组。对A、B两组患者的Hcy水平进行比较，并与对照组进行比较。依据HAMD评分对A组进行抑郁严重程度评估，并分为轻度抑郁、中度抑郁、重度抑郁三亚组，再比较各亚组间血清Hcy的水平。结果A、B两组与对照组比较，Hcy水平均明显增高，其差异具有统计学意义，且三组间进行两两比较，差异均具有统计学意义。A组中Hcy水平在轻、中、重度抑郁组中随HAMD评分升高而升高，呈正相关性（r=0.7545，P<0.05）。结论青壮年卒中及卒中后抑郁的发生与血清Hcy水平有关，且Hcy水平越高，抑郁程度越重。
목적：연구혈청중동형반광안산（Hcy）수평여청장년졸중후억욱적상관성。방법선2011년9월지2013년11월문진진치적80례18～45세뇌졸중환자（발병≥3주）위연구대상，기중35례졸중후억욱환자위A조，령45례졸중후미발생억욱자위B조，35례건강체검자위대조조。대A、B량조환자적Hcy수평진행비교，병여대조조진행비교。의거HAMD평분대A조진행억욱엄중정도평고，병분위경도억욱、중도억욱、중도억욱삼아조，재비교각아조간혈청Hcy적수평。결과A、B량조여대조조비교，Hcy수평균명현증고，기차이구유통계학의의，차삼조간진행량량비교，차이균구유통계학의의。A조중Hcy수평재경、중、중도억욱조중수HAMD평분승고이승고，정정상관성（r=0.7545，P<0.05）。결론청장년졸중급졸중후억욱적발생여혈청Hcy수평유관，차Hcy수평월고，억욱정도월중。
Objective To study the correlation of the serum homocysteine (Hcy) levels and young patients with post-stroke depression. Methods 80 cases of stroke patients (incidence 3 weeks) from 18 to 45 years old were selected who had been diagnosed and were treated from September, 2011 to November, 2013 in the outpatient of our hospital as the subjects of study. Among them, 35 cases with post-stroke depression were in Group A, the left 45 cases with post-stroke depression who had not been occurred in Group B, 35 cases of healthy people served as normal reference group. The serum homocysteine levels between Group A, B and the reference group were compared. According to HAMD score, the severity of depression in Group A were assessed, it was divided into mild depression, moderate depression and severe depression subgroup, then compared the serum homocysteine levels among the three subgroups. Results Compared with normal reference group, Hcy levels of Group A and B were signiifcantly higher, the difference was statistically signiifcant. Hcy levels of the three groups were compared respectively, all of the differences were statistically signiifcant. The Hcy levels of the mild, moderate and severe depression group in Group A were increased with the increase of HAMD score.The degree of depression and homocysteine levels were positively correlated (r=0.7545, P<0.05). Conclusion The occurrence of stroke and post-stroke depression in young adults were related with the Hcy levels of serum, and the higher of the Hcy levels is , the more severe degrees of depression are.