CAJ | 학술논문

目的：探讨甘露醇对急性颅内高压征危重患儿脑血流动力学的影响。方法：采用经颅多普勒（ TCD）监测25例急性颅内高压征危重患儿，使用甘露醇前、后大脑中动脉频谱形态和血流速度变化。结果：23例急性颅内高压患儿注射甘露醇0.5 h后收缩期峰流速（ Vp）、舒张期末血流速度（ Vd）、平均血流速度（ Vm）均增加，搏动指数（PI）降低（P﹤0.05），20例TCD频谱改变呈高阻力型，2例注射甘露醇前后均无脑血流信号。结论：急性颅内高压患儿使用甘露醇治疗可改善脑血流灌注，但对于TCD频谱变化明显异常、舒张期血流消失或反向血流的患儿甘露醇疗效不佳，预后差。
목적：탐토감로순대급성로내고압정위중환인뇌혈류동역학적영향。방법：채용경로다보륵（ TCD）감측25례급성로내고압정위중환인，사용감로순전、후대뇌중동맥빈보형태화혈류속도변화。결과：23례급성로내고압환인주사감로순0.5 h후수축기봉류속（ Vp）、서장기말혈류속도（ Vd）、평균혈류속도（ Vm）균증가，박동지수（PI）강저（P﹤0.05），20례TCD빈보개변정고조력형，2례주사감로순전후균무뇌혈류신호。결론：급성로내고압환인사용감로순치료가개선뇌혈류관주，단대우TCD빈보변화명현이상、서장기혈류소실혹반향혈류적환인감로순료효불가，예후차。
Objective:To explore the effect of mannitol on cerebral hemodynamics in patients with acute intracranial hyper-tension syndrome. Methods:25 cases with acute intracranial hypertension were detected by transcranial Doppler( TCD). The middle cerebral artery for target vessel,observe the frequency spectrum form and the blood flow velocity changes. Re-sults:23 cases of acute intracranial hypertension injected of mannitol after 0. 5 h,the peak velocity in systolic( Vp),the velocity in end diastolic(Vd),the mean flow velocities(Vm)were increased(P<0. 05),the pulsatility index(PI)de-creased(P<0. 05 ),20 cases of TCD spectrum changes showed high resistance type,2 cases had no cerebral blood flow signal before and after treatment with mannitol. Conclusions:Using mannitol therapy for patients with acute intracranial hypertension can improve cerebral blood flow perfusion,but the patients with TCD spectrum changed obviously abnormal, flow away in Diastolic,The reverse flow were Poor prognosis.