CAJ | 학술논문

目的：探讨n-3脂肪酸的膳食摄入量与结直肠癌发生风险的关系。方法计算机检索PubMed、EMBASE、CNKI数据库和Cochrane图书馆已发表的相关研究文献。由2名评价者独立筛选文章、提取数据及评价纳入研究的质量，采用STATA11.0软件完成Meta分析。结果最终共纳入7项病例对照研究和4项前瞻性队列研究，共253479名研究对象。n-3脂肪酸膳食摄入最高量部分的人群相比摄入最低量部分的人群发生结直肠癌的风险是0.88（95%CI：0.68~1.13；P=0.316，4分类，6项研究）和1.03（95%CI：0.92~1.16；P=0.606，5分类，5项研究）。结论 n-3脂肪酸的摄入量与结直肠癌的发生没有显著相关性，膳食摄入n-3脂肪酸与结直肠癌的发生风险之间的关系尚需进一步研究证实。
목적：탐토n-3지방산적선식섭입량여결직장암발생풍험적관계。방법계산궤검색PubMed、EMBASE、CNKI수거고화Cochrane도서관이발표적상관연구문헌。유2명평개자독립사선문장、제취수거급평개납입연구적질량，채용STATA11.0연건완성Meta분석。결과최종공납입7항병례대조연구화4항전첨성대렬연구，공253479명연구대상。n-3지방산선식섭입최고량부분적인군상비섭입최저량부분적인군발생결직장암적풍험시0.88（95%CI：0.68~1.13；P=0.316，4분류，6항연구）화1.03（95%CI：0.92~1.16；P=0.606，5분류，5항연구）。결론 n-3지방산적섭입량여결직장암적발생몰유현저상관성，선식섭입n-3지방산여결직장암적발생풍험지간적관계상수진일보연구증실。
Objective A meta analysis was conducted to examine the association between the dietary intake of n-3 fatty acids and colorectal cancer risk. Methods Articles published from Jan 1995 to May 2013 were identified through PubMed, EMBASE, CNKI and Cochrane Library database, and relevant references of the included studies were also retrieved. Two authors independently reviewed articles, extracted data and assessed the methodological quality. Meta-analyses were conducted by using STATA 11.0 software. Results A total of 7 case-control studies and 4 prospective cohort studies involving 253 479 participants were included. The pooled relative risks for the highest compared with the lowest n-3 fatty acids dietary intake were 0.88 (95%CI:0.68-1.13;P=0.316, quartiles of intake, 6 studies) and 1.03 (95%CI:0.92-1.16;P=0.606, quintile of intake, 5 studies) for colorectal cancer risk. Conclusions There is insufficient evidence to suggest a significant association between dietary intake of n-3 fatty acids and colorectal cancer incidence. The effect of dietary supplementation with n-3 fatty on colorectal cancer risk needs further investigation.