CAJ | 학술논문

目的：探讨乳腺叶状肿瘤的临床病理特征，分析肿瘤复发的相关因素。方法对2006年7月至2012年5月中山大学附属第三医院收治的60例乳腺叶状肿瘤患者的临床病理资料进行回顾性研究。结果良性组较交界性、恶性组平均病程长，发病年龄、肿瘤直径小，肿瘤血流供应少；良性组多呈膨胀性生长，细胞核轻度异型性，核分裂不活跃，肿瘤坏死少见，间质多无过度生长；而交界性、恶性组多呈浸润性生长，核大多有中至重度异型性，分裂活跃，可见肿瘤坏死，间质过度生长。肿瘤复发与病理类型、手术方式、核分裂及间质生长情况相关。结论良性叶状肿瘤比交界性、恶性叶状肿瘤发病早，进展慢，恶性程度低，侵袭性弱；肿瘤复发与肿瘤病理类型、手术方式、核分裂和间质生长情况相关。
목적：탐토유선협상종류적림상병리특정，분석종류복발적상관인소。방법대2006년7월지2012년5월중산대학부속제삼의원수치적60례유선협상종류환자적림상병리자료진행회고성연구。결과량성조교교계성、악성조평균병정장，발병년령、종류직경소，종류혈류공응소；량성조다정팽창성생장，세포핵경도이형성，핵분렬불활약，종류배사소견，간질다무과도생장；이교계성、악성조다정침윤성생장，핵대다유중지중도이형성，분렬활약，가견종류배사，간질과도생장。종류복발여병리류형、수술방식、핵분렬급간질생장정황상관。결론량성협상종류비교계성、악성협상종류발병조，진전만，악성정도저，침습성약；종류복발여종류병리류형、수술방식、핵분렬화간질생장정황상관。
Objective To explore the clinicopathologic features of phyllodes tumors (PT) of the breast and indentify predictive factors of local recurrence (LR). Methods Data of sixty women with PT were collected and analyzed from the Third Affiliated Hospital of Sun Yat-sen University. Results Compared with borderline and malignant tumors, the patients suffered from benign disease had longer clinical course, younger age, smaller tumor size and poorer blood supply. Tumors demonstrating pushing borders, mild cellular pleomorphism,unmarked stromal overgrowth, less mitoses or necrosis were more likely to be classified as benign, while invasive borders, moderate or severe cellular pleomorphism, marked stromal overgrowth and necrosis suggested borderline and malignant tumors. The pathological type, type of surgery, mitotic activity and stromal overgrowth were significantly correlated with recurrence. Conclusions Patients suffered from benign disease have younger age, longer clinical course, less malignancy and invasiveness. Patients with borderline or malignant tumors, receiving local excision, with high mitotic activity and marked stromal overgrowth are at high risk for recurrence.