CAJ | 학술논문

目的：介绍酒精戒断综合征（AWS）的机制、评估及药物治疗方面的进展。方法：对近年相关文献进行复习。结果：本文对 AWS 的时程、机制（尤其是涉及 GABA 及 NMDA 递质系统）、评估及药物治疗进行了介绍。详细讨论了固定剂量法及对症给药法的具体细节。对其他药物的使用也略有介绍。结论：AWS 比较常见且对酒精将具有诊断意义。长期饮酒导致的GABA/ NMDA 系统的改变是 AWS 的主要机制，长效苯二氮□类药是控制 AWS 的一线药物，不过其他药物也有使用。具体是使用固定剂量法还是对症给药法则以治疗环境、医生的偏好以及员工的培训情况而定。
목적：개소주정계단종합정（AWS）적궤제、평고급약물치료방면적진전。방법：대근년상관문헌진행복습。결과：본문대 AWS 적시정、궤제（우기시섭급 GABA 급 NMDA 체질계통）、평고급약물치료진행료개소。상세토론료고정제량법급대증급약법적구체세절。대기타약물적사용야략유개소。결론：AWS 비교상견차대주정장구유진단의의。장기음주도치적GABA/ NMDA 계통적개변시 AWS 적주요궤제，장효분이담□류약시공제 AWS 적일선약물，불과기타약물야유사용。구체시사용고정제량법환시대증급약법칙이치료배경、의생적편호이급원공적배훈정황이정。
Objective:To review the updates on mechanism of,and assessment and pharmacotherapy for alcohol Withdrawal syn-drome(AWS). Methods:Literature review and hand-picked literature. Results:We reviewed the time-course,mechanism(espe-cially mechanism related to GABA and NMDA systems),assessment and medications for AWS. Detailed discussions are provided re-garding fixed-dosed and symptom-triggered methods when using benzodiazepines for AWS. Role of other medications is also discussed. Conclusion:AWS is common and of diagnostic value in alcohol dependence. Alterations in GABA/ NMDA system after prolonged ex-posure to alcohol is believed to be the primary mechanism for AWS and long-acting benzodiazepines are the first-line pharmacotherapy, though other medications have been tried. Either fixed-dose or symptom-triggered method can be used,depending on the setting,clini-cians’preference and staff training.