CAJ | 학술논문

目的：探讨布拉酵母菌对婴幼儿肺炎继发抗生素相关腹泻（ AAD）的防治作用。方法选择1个月至3岁婴幼儿肺炎住院患者302例，均静脉应用抗菌药物且连续治疗＞5 d，排除慢性胃肠道疾病，随机分为对照组（ A组，60例）、布拉酵母菌治疗组（ B组，92例）和布拉酵母菌预防组（ C组，150例）。入选患儿在抗感染治疗的同时， C组加用布拉酵母菌，B组继发腹泻后加用布拉酵母菌，观察各组患儿AAD的发生情况，比较分析各组疗效。结果 C组患儿AAD发生率明显低于A、B组患儿；各组患儿继发腹泻严重程度差异无统计学意义（P＞0．05）；腹泻持续时间差异有统计学意义（P＜0．001），其中布拉酵母菌预防组腹泻持续时间最短，治疗组次之，对照组最长；抗腹泻总有效率差异有统计学意义（P＜0．05），A组抗腹泻总有效率不如C组，尚不能认为A组与B组、B组与C组间抗腹泻疗效有差别。结论婴幼儿肺炎继发AAD后，应用布拉酵母菌，可缩短腹泻病程；若预防性应用布拉酵母菌不仅能降低AAD的发病率，还能缩短腹泻病程，提高AAD治疗疗效，值得在临床工作中推广预防应用。
목적：탐토포랍효모균대영유인폐염계발항생소상관복사（ AAD）적방치작용。방법선택1개월지3세영유인폐염주원환자302례，균정맥응용항균약물차련속치료＞5 d，배제만성위장도질병，수궤분위대조조（ A조，60례）、포랍효모균치료조（ B조，92례）화포랍효모균예방조（ C조，150례）。입선환인재항감염치료적동시， C조가용포랍효모균，B조계발복사후가용포랍효모균，관찰각조환인AAD적발생정황，비교분석각조료효。결과 C조환인AAD발생솔명현저우A、B조환인；각조환인계발복사엄중정도차이무통계학의의（P＞0．05）；복사지속시간차이유통계학의의（P＜0．001），기중포랍효모균예방조복사지속시간최단，치료조차지，대조조최장；항복사총유효솔차이유통계학의의（P＜0．05），A조항복사총유효솔불여C조，상불능인위A조여B조、B조여C조간항복사료효유차별。결론영유인폐염계발AAD후，응용포랍효모균，가축단복사병정；약예방성응용포랍효모균불부능강저AAD적발병솔，환능축단복사병정，제고AAD치료료효，치득재림상공작중추엄예방응용。
Objective To investigate the therapeutic effect of Saccharomyces boulardii on antibiotics associated diarrhea (AAD)in infant pneumonia.Methods 302 hospitalized infant patients (1 month-3 years) with pneumonia but without gastroenteric disease were selected , and antibiotics were administrated intravenously at least 5 continuous days for each patient .Patients were all giv-en antibiotics and randomly divided into three groups:control group with no Saccharomyces boulardii administration ( group A, 60 ca-ses);Saccharomyces boulardii were applied as addition on the occurrence of diarrhea (group B, 92 cases), and Saccharomyces boular-dii and antibiotics were co-administrated (group C, 150 cases).Incidences of AAD in all groups were carefully examined and differ-ences of therapeutic effect between groups were compared and analyzed .Results The incidence of AAD in Group C was significantly lower than that in other groups .In term of diarrhea severity, no significant difference was observed in all groups (P>0.05).Howev-er, duration of diarrhea showed significant different between groups (P<0.001):group A with the longest duration and group C with the shortest .The results indicated that the total efficiency of anti-diarrhea in group C was significantly higher than that in control group (P<0.05).However, group B presented no significant difference compared with neither control group nor group C in term of therapeu -tic effect on diarrhea .Conclusion Administration of Saccharomyces boulardii Sachets could shorten the duration of diarrhea on the oc-currence of AAD in infant pneumonia .According to our results , Saccharomyces boulardii was effective in both preventing the develop-ment of AAD and shortening duration of diarrhea , and therefore improved therapeutic effect on ADD .