CAJ | 학술논문

目的：调查抗菌药物应用专项整治前后鲍曼不动杆菌的耐药情况和各类抗菌药物的使用强度，为后续干预策略提供证据。方法分析2011、2012年检出的562例鲍曼不动杆菌及药敏实验结果，结合各时间段每类抗菌药物使用情况进行分析。结果2011-2012年鲍曼不动杆菌半年检出菌数无明显差异；通过抗菌药物应用专项整治，β-内酰胺的使用强度（antibiotics use density，AUD）、氟喹诺酮和氨基糖苷类的AUD分别下降22．22（31．92％）、4．19（46．29％）、5．24（68．83％）；β-内酰胺类耐药率降幅明显，下降25％～30％；氟喹诺酮类和氨基糖苷类的耐药率也有所下降，从50％临界点下降至2012年下半年的20％～30％。结论规范各类抗菌药物的使用强度有助于降低细菌耐药性。
목적：조사항균약물응용전항정치전후포만불동간균적내약정황화각류항균약물적사용강도，위후속간예책략제공증거。방법분석2011、2012년검출적562례포만불동간균급약민실험결과，결합각시간단매류항균약물사용정황진행분석。결과2011-2012년포만불동간균반년검출균수무명현차이；통과항균약물응용전항정치，β-내선알적사용강도（antibiotics use density，AUD）、불규낙동화안기당감류적AUD분별하강22．22（31．92％）、4．19（46．29％）、5．24（68．83％）；β-내선알류내약솔강폭명현，하강25％～30％；불규낙동류화안기당감류적내약솔야유소하강，종50％림계점하강지2012년하반년적20％～30％。결론규범각류항균약물적사용강도유조우강저세균내약성。
Objective To investigate the drug resistance of Acinetobacter baumannii and antibiotics use density of all kinds of antibacterial drugs before and after special antibacterial drugs remediation , provide evidence for the follow-up intervention strategies . Methods The experimental results of detected 562 cases Acinetobacter baumannii and sensitivity test were analyzed in our hospital in 2011-2012 , combined with using of every type of antibacterial drugs on different time period .Results The number of bacteria detec-ted half year had no significant difference during 2011-2012 .The antibiotics use density of beta-lactam、fluroquinoloncs and aminogly-cosides declined 22.22(31.92%)、4.19(46.29%)、5.24(68.83%) respectively by special antibacterial drugs remediation .Beta-lactam resistance rates declined significantly to 25%~30%, fluroquinoloncs and aminoglycosides resistance rates also declined , from 50%of the critical point to 20%~30%in the second half of 2012 .Conclusion Standardization of antibiotics use density of various antibacterial drugs could help reduce bacterial resistance .