CAJ | 학술논문

小檗碱是从中草药黄连等植物中提取并分离得到的一类异喹啉类生物碱。近年来合成了大量小檗碱衍生物，并且发现了广泛的生理功能，其潜在的结构改造和开发应用价值很大。笔者对这些文献进行了较为系统的分析和整理，通过小檗碱不同位点的衍生物所展现的丰富的药理活性，为以小檗碱作为先导物进行的结构改造及创新药物提供了比较系统的信息。
소벽감시종중초약황련등식물중제취병분리득도적일류이규람류생물감。근년래합성료대량소벽감연생물，병차발현료엄범적생리공능，기잠재적결구개조화개발응용개치흔대。필자대저사문헌진행료교위계통적분석화정리，통과소벽감불동위점적연생물소전현적봉부적약리활성，위이소벽감작위선도물진행적결구개조급창신약물제공료비교계통적신식。
Berberine was an isoquinoline type alkaloid extracted from Chinese herbs such as Coptis chinensis.Recently, as a great many berberine derivatives had been synthesized with comprehensive physiological functions , the structural modification and ap-plication of berberine showed great promising significance .Recent literatures had been systematically analyzed and summarized in this review.With abundant pharmacological activities of berberine different sites ′derivatives had been presented , systematical information of berberine structural modification as a lead compound and new drug R&D were provided in this article .