CAJ | 학술논문

目的：探讨直接经皮冠状动脉介入（PCI）治疗联合静脉应用参麦注射液对急性前壁心肌梗死患者血浆醛固酮（ALD）、B型脑钠肽（BNP）水平和左心室重构的影响。方法将38例ST段抬高急性前壁心肌梗死行直接PCI患者分为两组：实验组（n=19）和对照组（n=19）。实验组在基础药物治疗基础上,于直接PCI术后予以静脉滴注参麦注射液（50mg/d）；对照组单给予基础药物治疗。两组患者于PCI术前、治疗2周、24周后分别抽血检测血浆ALD和BNP，治疗2周、24周后分别行超声心动描记术检测左心室重量（LVM）和室壁运动指数（WMSI）。结果两组患者在治疗2周时实验组ALD、BNP低于对照组，但差异均无统计学意义（均P＞0.05）；治疗24周时实验组ALD、BNP、WMSI显著低于对照组（均P＜0.01），LVEF显著高于对照组（P＜0.01）。结论急性前壁心肌梗直接PCI术后应用参麦注射液有利于改善左心室功能。
목적：탐토직접경피관상동맥개입（PCI）치료연합정맥응용삼맥주사액대급성전벽심기경사환자혈장철고동（ALD）、B형뇌납태（BNP）수평화좌심실중구적영향。방법장38례ST단태고급성전벽심기경사행직접PCI환자분위량조：실험조（n=19）화대조조（n=19）。실험조재기출약물치료기출상,우직접PCI술후여이정맥적주삼맥주사액（50mg/d）；대조조단급여기출약물치료。량조환자우PCI술전、치료2주、24주후분별추혈검측혈장ALD화BNP，치료2주、24주후분별행초성심동묘기술검측좌심실중량（LVM）화실벽운동지수（WMSI）。결과량조환자재치료2주시실험조ALD、BNP저우대조조，단차이균무통계학의의（균P＞0.05）；치료24주시실험조ALD、BNP、WMSI현저저우대조조（균P＜0.01），LVEF현저고우대조조（P＜0.01）。결론급성전벽심기경직접PCI술후응용삼맥주사액유리우개선좌심실공능。
Objective To evaluate the effects of Shenmai injection with primary percutaneous coronary intervention (PCI) on aldosterone, B- type natriuretic peptide (BNP)and left ventricular function in patients with acute anterior myocardial infarction (AAMI). Methods 38 patients underwent primary PCI for AAMI were randomized divided into Shenmai group(n=19) and control group(n=19). Al patients received regular therapy. Patients in Shenmai group received Shenmai injection 50mg/d for 15 days on the basis of regular therapy. The serum ALD and BNP were measured before, 2 weeks and 24 weeks after PCI. Echocardiography was performed at 2 weeks and 24 weeks after PCI. Results The levels of ALD and BNP were not significantly different between Shenmai and control groups at 2 weeks, but significantly lower in Shenmai group than control group at 24 weeks. Wal motion index was significantly lower, and left ventricular ejection fraction was significantly higher in Shenmai group than control group at 24 weeks (al P<0.01). Conclusion Shenmai injection may improve left ventricular function in patients with AAMI after primary PCI.