现代农药
現代農藥
현대농약
MODERN AGROCHEMICALS
2014年
3期
25-27
,共3页
李伟%李玉峰%左杭冬%吴晓伟%马鸿飞%卜洪忠
李偉%李玉峰%左杭鼕%吳曉偉%馬鴻飛%蔔洪忠
리위%리옥봉%좌항동%오효위%마홍비%복홍충
4-三氟甲基烟酸%氟啶虫酰胺%三氟乙酰乙酸乙酯%氰基乙酰胺%合成
4-三氟甲基煙痠%氟啶蟲酰胺%三氟乙酰乙痠乙酯%氰基乙酰胺%閤成
4-삼불갑기연산%불정충선알%삼불을선을산을지%청기을선알%합성
4-(trifluoromethyl)nicotinic acid%flonicamid%4,4,4-trifluoroacetoacetate%cyanoacetamide%synthesis
4-三氟甲基烟酸是高效杀虫剂氟啶虫酰胺的重要中间体。以三氟乙酰乙酸乙酯和氰基乙酰胺为原料，经环合、氯代、氢化还原、水解反应得到目标产物。经优化反应条件，以三氟乙酰乙酸乙酯计4-三氟甲基烟酸的总收率达到38.6%。该路线原料易得、收率高，适合工业化生产。
4-三氟甲基煙痠是高效殺蟲劑氟啶蟲酰胺的重要中間體。以三氟乙酰乙痠乙酯和氰基乙酰胺為原料，經環閤、氯代、氫化還原、水解反應得到目標產物。經優化反應條件，以三氟乙酰乙痠乙酯計4-三氟甲基煙痠的總收率達到38.6%。該路線原料易得、收率高，適閤工業化生產。
4-삼불갑기연산시고효살충제불정충선알적중요중간체。이삼불을선을산을지화청기을선알위원료，경배합、록대、경화환원、수해반응득도목표산물。경우화반응조건，이삼불을선을산을지계4-삼불갑기연산적총수솔체도38.6%。해로선원료역득、수솔고，괄합공업화생산。
4-(Trifluoromethyl)nicotinic acid was an important intermediate for the preparation of flonicamid. With ethyl 4,4,4-trifluoroacetoacetate and cyanoacetamide as starting materials, the desired product was prepared via optimized cyclization, chlorination, hydrogenolysis, hydrolysis. The total yield was 38.6%based on ethyl 4,4,4-trifluoroacetoacetate. The method benefited from readily available materials, satisfactory yield, and was suitable for industrial production.
