CAJ | 학술논문

启动子是调控基因表达的重要基因元件，它的调控作用是多层次多因素共同作用的结果。通过启动子的调控能够控制基因表达的水平、部位及方式。深入研究启动子对于了解生物的生长发育、防御系统、疾病等都有非常重要的意义。本文综述了启动子克隆、生物信息学分析和预测的方法，比较了两种启动子分析方法，介绍了启动子甲基化、多态性和合成启动子的研究进展，以期能够为启动子的研究提供参考。
계동자시조공기인표체적중요기인원건，타적조공작용시다층차다인소공동작용적결과。통과계동자적조공능구공제기인표체적수평、부위급방식。심입연구계동자대우료해생물적생장발육、방어계통、질병등도유비상중요적의의。본문종술료계동자극륭、생물신식학분석화예측적방법，비교료량충계동자분석방법，개소료계동자갑기화、다태성화합성계동자적연구진전，이기능구위계동자적연구제공삼고。
Promoter is an important element in regulation of gene expression. The regulation role of promoter is the result of a multi-level interaction of multiple factors. The level, location and manner of gene expression are regulated by the promoter, so deeply study of promoter is of great importance for understanding biological growth, defense system and disease. This paper reviews the methods of promoter cloning, bioinformatics analysis and forecasting of promoter, compares two methods of promoter analysis, introduces the progress of promoter methylation and polymorphism, so as to provide a reference for further study of promoters.