CAJ | 학술논문

采用氮烷基化、羟基保护、醛酮缩合的三步反应合成了8个新型单羰基姜黄素类似物，结构经质谱、核磁共振氢谱和核磁共振碳谱等手段进行确认.并采用 MTT 染色法体外检测所合成的单羰基姜黄素类似物对肺癌细胞 H1299、结肠癌细胞 HT-29、胰腺癌细胞 BxPC-3和前列腺癌细胞 PC-3的抗肿瘤活性.半数抑制浓度 IC50值结果显示：所合成的8个姜黄素类似物对4种肿瘤细胞均有较强的抑制作用，其中化合物 A6半数抑制浓度 IC50均在0.65μmol/ L 以下，抗癌活性比姜黄素提高40倍以上.
채용담완기화、간기보호、철동축합적삼보반응합성료8개신형단탄기강황소유사물，결구경질보、핵자공진경보화핵자공진탄보등수단진행학인.병채용 MTT 염색법체외검측소합성적단탄기강황소유사물대폐암세포 H1299、결장암세포 HT-29、이선암세포 BxPC-3화전렬선암세포 PC-3적항종류활성.반수억제농도 IC50치결과현시：소합성적8개강황소유사물대4충종류세포균유교강적억제작용，기중화합물 A6반수억제농도 IC50균재0.65μmol/ L 이하，항암활성비강황소제고40배이상.
Eight mono-carbonyl curcumin analogues were synthesized by a three-step reaction of alkylation,hydrox-yl protection,and aldehyde ketone condensation. Their structures were characterized by 1 H NMR and ESI-MS tech-niques. All the compounds were evaluated for their effects on cultured prostate cancer PC-3 cells,pancreas cancer BxPC-3 cells,colon cancer HT-29 cells and lung cancer H1299 cells. These compounds exhibited inhibitory effects on the growth of cultured PC-3,BxPC-3,HT-29 and H1299 cells. The IC50 of compound A6 was lower than 0. 65μmol/ L in all four cell lines,and A6 was 40-fold more active than curcumin.