CAJ | 학술논문

目的：检测红丝线草的致畸性。方法：红丝线草提取液设10.0、5.0、2.5 g/kg 3个剂量组，同时以去离子水作阴性对照，阿司匹林(0.3 g/kg)作阳性对照。每组12只SD孕鼠，受孕6 d开始按10 mL/kg给孕鼠灌胃受试溶液，每天1次，至受孕15 d，共灌胃10次。于妊娠20 d解剖孕鼠，检查胎鼠的身体、外观、内脏及骨骼发育等指标。结果：红丝线草各剂量组的孕鼠体质量、窝质量、胎鼠体质量、身长、尾长、活胎率、吸收胎率及死胎率与阴性对照组比较差异均无统计学意义(P均>0.05)，未见胎鼠外观、内脏和骨骼发育异常及畸形。结论：在本实验条件下，红丝线草对大鼠无母体毒性、胚胎毒性和致畸性。
목적：검측홍사선초적치기성。방법：홍사선초제취액설10.0、5.0、2.5 g/kg 3개제량조，동시이거리자수작음성대조，아사필림(0.3 g/kg)작양성대조。매조12지SD잉서，수잉6 d개시안10 mL/kg급잉서관위수시용액，매천1차，지수잉15 d，공관위10차。우임신20 d해부잉서，검사태서적신체、외관、내장급골격발육등지표。결과：홍사선초각제량조적잉서체질량、와질량、태서체질량、신장、미장、활태솔、흡수태솔급사태솔여음성대조조비교차이균무통계학의의(P균>0.05)，미견태서외관、내장화골격발육이상급기형。결론：재본실험조건하，홍사선초대대서무모체독성、배태독성화치기성。
OBJECTIVE:To determine the teratogenic effects of peristrophe roxburghiana (Schult.) brem in rats. METHODS:Pregnant rats were divided into 5 groups,each with 12 rats. Three groups were treated orally with th thexract from peristrophe roxburghiana for 10 days from 6 to 15 day of pregnancy with doses of 10.0,5.0,2.5 g/kg. The other two groups were fed orally with deionized water as negative control and aspirin with 0.3 g/kg as positive control. At th20 day,the rats were sacrificed to allow physical examination of the fetuses. RESULTS:In all treated groups the body weight of parental rats, litter weight, live rate, fetus body weight and fetus length were not significantly different from negative control group (P>0.05),and no abnormality of organ or external was found in the fetuses. CONCLUSION:In these experimental conditions,peristrophe roxburghiana had no appearance maternal toxicity,embryo toxicity nor teratogenicity in rats.