CAJ | 학술논문

目的：介绍类风湿性关节炎模型的研究进展，进行中药药效评价思考。方法对近十几年来国内外相关文献对关节炎模型的报道进行整理、分析与归纳。结果与结论目前主要有佐剂性关节炎和胶原诱导性关节炎模型等，应该根据中药自身的特点选择合适的动物模型，进行候选药物筛选和药效评价，并将类风湿性关节炎动物模型的研究与临床疾病研究紧密地结合起来，为临床前中药药理研究与药效评价提供方法学保证。
목적：개소류풍습성관절염모형적연구진전，진행중약약효평개사고。방법대근십궤년래국내외상관문헌대관절염모형적보도진행정리、분석여귀납。결과여결론목전주요유좌제성관절염화효원유도성관절염모형등，응해근거중약자신적특점선택합괄적동물모형，진행후선약물사선화약효평개，병장류풍습성관절염동물모형적연구여림상질병연구긴밀지결합기래，위림상전중약약리연구여약효평개제공방법학보증。
Objective To introduce the research development on the establishments of animal models with rheumatoid arthritis, and think about efficacy evaluation of TCM. Methods References in the last decades at home and abroad about RA model were collated, analyzed and summarized. Results and Conclusion The main RA model are AA, CIA and so on. We should select suitable animal model on the basis of TCM's characteristic to screen out medicine and to evaluate the efficacy of medicine, and combine closely the research of RA's animal model with clinical disease to ensure the stability and reliability of animal model. And then to offer methodological ensurance for TCM's pharmacological preclinical research and efficacy evaluation.