CAJ | 학술논문

目的：探讨赤芍与白芍脐中穴给药药理作用差异。方法：选择脐中穴为给药部位，考察赤芍、白芍贴膏剂脐中穴贴敷对二甲苯所致小鼠耳肿胀、醋酸致小鼠扭体反应以及ADP和凝血酶诱导的血小板聚集的影响。结果：与空白对照组比较，赤芍贴膏剂组有显著的镇痛和抑制血小板聚集作用（P ＜0.05），白芍贴膏剂组具有显著的镇痛作用（P＜0．05），散结镇痛胶囊及桂枝茯苓贴膏剂有显著的抗炎、镇痛及抗血小板聚集作用（P＜0．05），赤芍、白芍贴膏剂组对二甲苯致小鼠耳肿胀和空白组相比虽无显著性差异，但都呈一定作用趋势。桂枝茯苓贴膏剂组与赤芍贴膏剂组相比，也都有作用增强趋势，但无显著性差异。结论：赤芍脐中穴给药具有止痛、抗血小板聚集作用，白芍脐中穴给药具有止痛作用。
목적：탐토적작여백작제중혈급약약리작용차이。방법：선택제중혈위급약부위，고찰적작、백작첩고제제중혈첩부대이갑분소치소서이종창、작산치소서뉴체반응이급ADP화응혈매유도적혈소판취집적영향。결과：여공백대조조비교，적작첩고제조유현저적진통화억제혈소판취집작용（P ＜0.05），백작첩고제조구유현저적진통작용（P＜0．05），산결진통효낭급계지복령첩고제유현저적항염、진통급항혈소판취집작용（P＜0．05），적작、백작첩고제조대이갑분치소서이종창화공백조상비수무현저성차이，단도정일정작용추세。계지복령첩고제조여적작첩고제조상비，야도유작용증강추세，단무현저성차이。결론：적작제중혈급약구유지통、항혈소판취집작용，백작제중혈급약구유지통작용。
Objective:To explore the effect of difference between radix paeoniae rubra and radix paeoniae alba in the umbilical acupuncture point for pharmacological action .Methods:Select the umbilical acupuncture point for drug delivery .Investigate radix paeoniae rubra , radix paeoniae alba emplastrum umbilical acupuncture point sticking on mice ear swelling caused by dimethylbenzene , acetic acid in mice body torsion reaction and the in-fluence of the platelet aggregation induced by ADP and thrombin .Results:Compared with blank control group , radix paeoniae rubra emplastrum group had significantly analgesic action and inhibited platelet aggregation ( P<0 .05 );Radix paeoniae alba emplastrum group had a significantly analgesic action ( P<0 .05 );Sanjie analgesic capsule and cassia twig tuckahoe emplastrum had an obvious anti -inflammation and analgesic action and plate-let aggregation ( P<0.05 );Radix paeoniae rubra , radix paeoniae alba emplastrum group on mice ear swelling induced by xylene and compared with blank group , there was no significant difference , but all showed a trend of effects .Cassia twig tuckahoe emplastrum group and radix paeoniae rubra emplastrum compared group , also had an effect on enhancing trend , but there was no significant difference .Conclusion:Radix paeoniae rubra in um-bilical acupuncture point has analgesic action , anti platelet aggregation ,and root of herbaceous peony in the um-bilical acupuncture point to medicine has an analgesic effect .