中国药物警戒
中國藥物警戒
중국약물경계
CHINESE JOURNAL OF PHARMACOVIGILANCE
2014年
5期
288-290
,共3页
鸦胆子%过敏反应%过敏性休克%眼损伤%药品不良反应/事件
鴉膽子%過敏反應%過敏性休剋%眼損傷%藥品不良反應/事件
아담자%과민반응%과민성휴극%안손상%약품불량반응/사건
Brucea javanica%allergy%allergic shock%eye injury%adverse drug reaction/event
目的：探讨鸦胆子外用致不良反应/事件的一般规律，为临床合理用药提供参考。方法通过检索1958～2012年《中国期刊全文数据库》，对收集到的35例鸦胆子外用致不良反应/事件的文献报道进行统计分析。结果35例病例报告中急性过敏反应29例，通常发生在用药后60min内,18例发生在用药5min内，其中过敏性休克20例；发生急性眼部损伤4例，表现为眼部疼痛、异物感、畏光流泪、视物模糊、视力下降；发生表皮松解坏死型皮炎、右足背及右下肢肿胀各1例。结论鸦胆子外用可引起严重药品不良反应/事件，须加强其致药品不良反应/事件的研究及防治。
目的：探討鴉膽子外用緻不良反應/事件的一般規律，為臨床閤理用藥提供參攷。方法通過檢索1958～2012年《中國期刊全文數據庫》，對收集到的35例鴉膽子外用緻不良反應/事件的文獻報道進行統計分析。結果35例病例報告中急性過敏反應29例，通常髮生在用藥後60min內,18例髮生在用藥5min內，其中過敏性休剋20例；髮生急性眼部損傷4例，錶現為眼部疼痛、異物感、畏光流淚、視物模糊、視力下降；髮生錶皮鬆解壞死型皮炎、右足揹及右下肢腫脹各1例。結論鴉膽子外用可引起嚴重藥品不良反應/事件，鬚加彊其緻藥品不良反應/事件的研究及防治。
목적：탐토아담자외용치불량반응/사건적일반규률，위림상합리용약제공삼고。방법통과검색1958～2012년《중국기간전문수거고》，대수집도적35례아담자외용치불량반응/사건적문헌보도진행통계분석。결과35례병례보고중급성과민반응29례，통상발생재용약후60min내,18례발생재용약5min내，기중과민성휴극20례；발생급성안부손상4례，표현위안부동통、이물감、외광류루、시물모호、시력하강；발생표피송해배사형피염、우족배급우하지종창각1례。결론아담자외용가인기엄중약품불량반응/사건，수가강기치약품불량반응/사건적연구급방치。
Objective To investigate the epidemiological characteristics of adverse drug reactions/event (ADR/ADE) induced by Brucea javanica. Methods With retrospective case study, analyzed 35 cases of ADR/ADE induced by Brucea javanica, which were searched from Chinese Journal Full-text Database between1958 and 2012. Results 29 cases were acute allergy, including 20 allergic shock cases. Acute allergy usually occurred in 60 min after drug treatment, 18 cases occurred in 5 min after drug treatment. 4 cases were acute eye injury, manifested as eye pain, foreign body sensation, photophobia, blurred vision and severe vision loss. Other clinical manifestations were epidermolytic necrotizing dermatitis(1case) and right lower limb swelling(1 case). Conclusion Brucea javanica for topical use may induce serious ADR/ADE, which should be strengthened to observe and evaluate.
