CAJ | 학술논문

目的：探索辛夷药材中辛夷脂素的分离精制工艺，进行辛夷脂素的抗过敏作用的实验研究。方法分析鉴定从辛夷中提取的单体成分结构。观察单体成分对抗过敏性毛细血管通透性增强实验和对小鼠皮肤被动过敏反应的作用。结果经过UV、IR、MS、13C-NMR确定了此单体成分的结构，证实为辛夷脂素。辛夷脂素对抗过敏性毛细血管通透性增强和对小鼠皮肤被动过敏反应有效。结论辛夷脂素是辛夷的主要活性成分之一，具有抗过敏性毛细血管通透性增强的作用和抗小鼠皮肤被动过敏反应的作用，并呈现一定的剂量依赖关系。
목적：탐색신이약재중신이지소적분리정제공예，진행신이지소적항과민작용적실험연구。방법분석감정종신이중제취적단체성분결구。관찰단체성분대항과민성모세혈관통투성증강실험화대소서피부피동과민반응적작용。결과경과UV、IR、MS、13C-NMR학정료차단체성분적결구，증실위신이지소。신이지소대항과민성모세혈관통투성증강화대소서피부피동과민반응유효。결론신이지소시신이적주요활성성분지일，구유항과민성모세혈관통투성증강적작용화항소서피부피동과민반응적작용，병정현일정적제량의뢰관계。
Objective To explore purification conditions of fargesin in Magnolia and conduct its experimental study of anti-allergic effect. Methods The structure of monomer composition from Magnolia was analyzed and identified. The effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice from the monomer composition were explored. Results The monomer composition was confirmed to be fargesin by UV, IR, MS and 13C-NMR. And it was considered to be effective to the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice. Conclusion Fargesin, as one of the most effective components, presents a certain dose-efficacy relationship in the terms of the effects on the experiments of anti-permeability strengthening of allergenic capillary vessels and passive anaphylaxis of the skin on mice.