CAJ | 학술논문

目的：探讨 Bcl-2、VEGF、MMP-2在结肠黏液腺癌中的表达及其与临床预后资料的关系。方法应用免疫组织化学及组织芯片技术，对91例结肠黏液腺癌及癌旁组织 Bcl-2、VEGF、MMP-2的表达进行检测。结果结肠黏液腺癌中 Bcl-2、VEGF、MMP-2的表达率分别为68．13％、53．85％和60．43％，癌旁组织中三者表达的阳性率分别为36．26％、30．76％和25．27％，三项指标各组相比差异有统计学意义（P ＜0．05）。Bcl-2、VEGF、MMP-2在结肠黏液腺癌中的表达与癌组织病理分化程度、TNM 分期，淋巴结转移比较差异具有统计学意义（P ＜0．05），但与年龄和性别无关（P ＞0．05）。结论结肠黏液腺癌的发展，侵袭，转移与 Bcl-2、VEGF、MMP-2的过度表达相关，三者具有协同作用，联合检测可以判断结肠黏液腺癌的恶性程度及预后。
목적：탐토 Bcl-2、VEGF、MMP-2재결장점액선암중적표체급기여림상예후자료적관계。방법응용면역조직화학급조직심편기술，대91례결장점액선암급암방조직 Bcl-2、VEGF、MMP-2적표체진행검측。결과결장점액선암중 Bcl-2、VEGF、MMP-2적표체솔분별위68．13％、53．85％화60．43％，암방조직중삼자표체적양성솔분별위36．26％、30．76％화25．27％，삼항지표각조상비차이유통계학의의（P ＜0．05）。Bcl-2、VEGF、MMP-2재결장점액선암중적표체여암조직병리분화정도、TNM 분기，림파결전이비교차이구유통계학의의（P ＜0．05），단여년령화성별무관（P ＞0．05）。결론결장점액선암적발전，침습，전이여 Bcl-2、VEGF、MMP-2적과도표체상관，삼자구유협동작용，연합검측가이판단결장점액선암적악성정도급예후。
Objective To investigate the relationship of clinical prognosis and Bcl-2,VEGF and MMP-2 protein ex-pression in colon mucinous adenocarcinoma.Methods The expression of Bcl-2,VEGF,MMP-2 in 91 cases of colon cancer and precancerous tissue was detected by immunohistochemistry method.Results The positive rates of Bcl-2, VEGF and MMP-2 in colon carcinoma were 68.13%,53.85% and 60.43% respectively.They were 36.26%,30.76%and 25.27% in precancerous tissue.The difference was statistically significant(P <0.05).expression of Bcl-2,VEGF, MMP-2 in colorectal cancer had statistics significance with degree of differentiation,TNM staging,lymph node metasta-sis (P <0.05),but it wasn’t significant with age and sex(P >0.05).Conclusion Overexpression of Bcl-2,VEGF, MMP-2 in colon cancer play an important role in the occurrence and development of colon cancer.There is a synergy. Joint detection of them has important value in the malignancy and judgement prognosis of colorectal cancer.