CAJ | 학술논문

目的：探讨血清胱抑素 C（CysC）、血清超敏 C 反应蛋白（hsCRP）、尿微量白蛋白（U-mAlb）和尿β2-微球蛋白（β2-MG）对诊断早期糖尿病肾病（DN）的应用价值。方法根据尿微量白蛋白水平将70例 DN 患者分为尿蛋白正常组（A 组）20例，尿蛋白少量组（B 组）27例，尿蛋白大量组（C 组）23例，另外选取健康对照组30例，同时检测各组患者的血清 CysC、hsCRP、尿β2-MG 和 U-mAlb 水平。结果与 A 组和对照组比较，B 组和 C 组各项指标水平有显著统计学差异（P ＜0．01），A 组与对照组比较血清 CysC、hsCRP 水平差异有统计学意义（P ＜0．05），DN 组上述四项指标水平各组间存在显著性差异（P ＜0．01）。结论联合检测血清 CYS-C、hsCRP、U-mAlb 和尿β2-MG 水平可作为DN 早期肾损伤敏感指标，全面协助 DN 的早期诊断。
목적：탐토혈청광억소 C（CysC）、혈청초민 C 반응단백（hsCRP）、뇨미량백단백（U-mAlb）화뇨β2-미구단백（β2-MG）대진단조기당뇨병신병（DN）적응용개치。방법근거뇨미량백단백수평장70례 DN 환자분위뇨단백정상조（A 조）20례，뇨단백소량조（B 조）27례，뇨단백대량조（C 조）23례，령외선취건강대조조30례，동시검측각조환자적혈청 CysC、hsCRP、뇨β2-MG 화 U-mAlb 수평。결과여 A 조화대조조비교，B 조화 C 조각항지표수평유현저통계학차이（P ＜0．01），A 조여대조조비교혈청 CysC、hsCRP 수평차이유통계학의의（P ＜0．05），DN 조상술사항지표수평각조간존재현저성차이（P ＜0．01）。결론연합검측혈청 CYS-C、hsCRP、U-mAlb 화뇨β2-MG 수평가작위DN 조기신손상민감지표，전면협조 DN 적조기진단。
Objective To investigate the diagnosis value of serum cystain C(Cys-C),high sensitive C-reactive pro-tein(hsCRP),urinary albumin(U-mAlb)and Urineβ2 # microglobulin(β2-MG )in the early diabetics nephropathy. Methods According to urinary album level,the 70 patients with diabetes were divided into three groups:the normal al-buminuria group(the group A)20 cases,the micro albuminuria group(the group B)27 patients,and the clinical proteinu-ria group(the group C)23 cases,and select the healthy control group 30 subjects.The levels of four groups's Cys-C, hsCRP,U-mAlb,β2-MG were detected.Results Compared with the group A and control group,the levels of four indi-cators of the group B and the group C both significantly increased (P <0.01),the levels of Cys-C、hsCRP of the group A were significantly higher than the control group,(P <0.05),The levels of four indicators were significantly higher in the diabetics nephropathy groups(P <0.01).Conclusion Joint detection of serum Cys-C,hsCRP,U-mAlb and Urineβ2-MG levels as early renal injury sensitive indicators and full assistance to the early diagnosis of diabetics nephropathy.