CAJ | 학술논문

目的：探讨维持血液透析患者红细胞谷胱甘肽 S 转移酶（GST）水平及其与透析充分性及炎症因子的相关性。方法根据单位室模型尿素指数值（spKt/V）将84例长期维持血液透析的终末期患者分为血液透析充分组（sp-Kt/V≥1．3）33例以及血液透析不充分组（spKt/V＜1．3）51例，另选取50例健康体检者为对照组，对比分析三组患者相关临床及生化指标的差异。结果血液透析组 GST、肌酐、超敏 C 反应蛋白（hs-CRP）、转铁蛋白饱和度（TSAT）、甲状旁腺素（PTH）、白细胞介素-2、6、8（IL-2、6、8）及肿瘤坏死因子-a（TNF-a）水平显著高于对照组（P ＜0.05），且血液透析不充分组 GST、IL-2、6、8、TNF-a 水平显著高于血液透析充分组（P ＜0．05）。经 Pearson’s 相关分析可知，GST与 spKt/V、IL-2、IL-6、IL-8、TNF-a 呈正相关（均 P ＜0．05），而与肌酐、hs-CRP、TSAT、PTH 无相关性（P ＞0．05）。对51例血液透析不充分患者调整透析方案后有23例患者 spKt/V≥1．3，经调整后患者 GST 水平显著低于调整前，但仍高于充分透析组。结论维持血液透析患者 GST 水平与 spKt/V 及相关炎症因子具有一定的相关性，通过测定GST 可有效反映血液透析充分性，对临床调整血液透析方案具有指导意义。
목적：탐토유지혈액투석환자홍세포곡광감태 S 전이매（GST）수평급기여투석충분성급염증인자적상관성。방법근거단위실모형뇨소지수치（spKt/V）장84례장기유지혈액투석적종말기환자분위혈액투석충분조（sp-Kt/V≥1．3）33례이급혈액투석불충분조（spKt/V＜1．3）51례，령선취50례건강체검자위대조조，대비분석삼조환자상관림상급생화지표적차이。결과혈액투석조 GST、기항、초민 C 반응단백（hs-CRP）、전철단백포화도（TSAT）、갑상방선소（PTH）、백세포개소-2、6、8（IL-2、6、8）급종류배사인자-a（TNF-a）수평현저고우대조조（P ＜0.05），차혈액투석불충분조 GST、IL-2、6、8、TNF-a 수평현저고우혈액투석충분조（P ＜0．05）。경 Pearson’s 상관분석가지，GST여 spKt/V、IL-2、IL-6、IL-8、TNF-a 정정상관（균 P ＜0．05），이여기항、hs-CRP、TSAT、PTH 무상관성（P ＞0．05）。대51례혈액투석불충분환자조정투석방안후유23례환자 spKt/V≥1．3，경조정후환자 GST 수평현저저우조정전，단잉고우충분투석조。결론유지혈액투석환자 GST 수평여 spKt/V 급상관염증인자구유일정적상관성，통과측정GST 가유효반영혈액투석충분성，대림상조정혈액투석방안구유지도의의。
Objective To investigate the levels of glutathione S-transferase (GST)and adequacy and relevance of in-flammatory cytokines with hemodialysis patients erythrocyte.Methods 84 cases of long-term hemodialysis patients were deviced into hemodialysis group (spKt/V≥1.3)33 cases and inadequate hemodialysis group (spKt/V<1.3)51 cases.50 healthy volunteers were selected as the control group.The clinical and biochemical of three groups were com-paratived.Results The levels of C-reactive protein (hs-CRP),transferrin saturation (TSAT),parathyroid hormone (PTH),interleukin-2,6,8 (IL-2,6,8 )and tumor necrosis factor-a (TNF-a)of hemodialysis were significantly higher than control group(P <0.05),and the levels of GST,IL-2,6,8,TNF-a of inadequate hemodialysis group were higher than hemodialysis adequacy group (P <0.05).The Person's single-factor analysis shows,GST and spKt/V,IL-2,6,8, TNF-a was positively correlated (all P <0.05),and creatinine,hs-CRP,TSAT,PTH was not correlated (P >0.05).51 cases of inadequate hemodialysis patients after adjustment program has 23 dialysis patients spKt/V≥1.3,after adjust-ment GST patients was significantly lower than before the adjustment,but still higher than adequate dialysis.Conclusion hemodialysis patients GST levels spKt/V and related inflammatory factors has some relevance,by measuring the GST can effectively reflect hemodialysis adequacy,adjusting for clinical hemodialysis program has guiding significance.