CAJ | 학술논문

目的：探讨维持性血液透析（MHD）合并脑梗死（CI）患者血清 IL-1β、IL-6及 hs-CRP 水平的变化及意义。方法将20例 MHD 合并 CI 的患者纳入 MHD＋CI 组，随机选择同期未合并 CI 的 MHD 患者20例纳入 MHD 组，并选取与 MHD 患者年龄、性别相匹配的20例健康体检者纳入对照组，比较各组血清 IL-1β、IL-6及 hs-CRP 水平。结果MHD 组及 MHD＋ CI 组中血清 IL-1β、IL-6及 hs-CRP 含量明显高于对照组，差异有统计学意义（P ＜0．05）；而MHD＋ CI 组中血清 IL-1β、IL-6及 hs-CRP 含量明显高于 MHD 组，差异有统计学意义（P ＜0．05）。结论MHD 患者普遍存在微炎症状态，且血清 IL-1β、IL-6及 hs-CRP 在 MHD 患者脑梗死的发生发展中具有重要作用。
목적：탐토유지성혈액투석（MHD）합병뇌경사（CI）환자혈청 IL-1β、IL-6급 hs-CRP 수평적변화급의의。방법장20례 MHD 합병 CI 적환자납입 MHD＋CI 조，수궤선택동기미합병 CI 적 MHD 환자20례납입 MHD 조，병선취여 MHD 환자년령、성별상필배적20례건강체검자납입대조조，비교각조혈청 IL-1β、IL-6급 hs-CRP 수평。결과MHD 조급 MHD＋ CI 조중혈청 IL-1β、IL-6급 hs-CRP 함량명현고우대조조，차이유통계학의의（P ＜0．05）；이MHD＋ CI 조중혈청 IL-1β、IL-6급 hs-CRP 함량명현고우 MHD 조，차이유통계학의의（P ＜0．05）。결론MHD 환자보편존재미염증상태，차혈청 IL-1β、IL-6급 hs-CRP 재 MHD 환자뇌경사적발생발전중구유중요작용。
Objective To investigate the clinical significance of serum IL-1β,IL-6 and hs-CRP changes in mainte-nance hemodialysis(MHD)patients with cerebral infarction(CI).Methods 20 MHD patients with CI were included in-to the MHD + CI group,and 20 MHD patients without CI were randomly selected into the MHD group,and 20 healthy person with age and sex-matched MHD patients were included into the control group,the serum IL-1β,IL-6 and hs-CRP levels were compared.Results The levels of serum IL-1β,IL-6 and hs-CRP in MHD and MHD + CI group were sig-nificantly higher than the control group,the difference was of statistically significant (P <0.05);the serum IL-1β,IL-6 and hs-CRP levels in MHD + CI group were significantly higher than the MHD group,the difference was of statistical-ly significant (P <0.05).Conclusion The micro-inflammation is prevalence in MHD patients,and the serum IL-1β,IL-6 and hs-CRP plays an important role in the development of cerebral infarction in MHD patients.