中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2014年
5期
733-735
,共3页
早期糖尿病肾病%CysC%Hcy%U-mAlb%联合检测
早期糖尿病腎病%CysC%Hcy%U-mAlb%聯閤檢測
조기당뇨병신병%CysC%Hcy%U-mAlb%연합검측
Early diabetic nephropathy%CysC%Hcy%U-mAlb%cinjoined detection
目的:探讨血清胱抑素(Cystatin,CysC)、同型半胱氨酸(Homocysteine,Hcy)和尿微量清蛋白(Urinary mi-croalbuminuria,U-mAlb)联合检测在早期糖尿病肾病(Early diabetic nephropathy,DN)诊断中的临床应用。方法选择112例糖尿病患者,根据临床诊断将其分为 DN 尿蛋白阳性组40例(A 组)、DN 尿蛋白阴性组35例(B 组)、糖尿病无肾损害组37例(C 组),同时选择同期来医院健康体检的健康者40例作为对照(对照组),分别测定3组对象血清CysC、Hcy 和 U-mAlb 水平,并进行统计学比较。结果A 组和 B 组 CysC、Hcy 和 U-mAlb 水平明显高于 C 组和对照组(P <0.05),其中 A 组3项指标水平升高最为显著(P <0.05)。A 组和 B 组的阳性检出率明显高于 C 组和对照组(P <0.05),且阳性率随着患者肾损害程度的加重而升高。B 组3项指标联合检测的诊断阳性率为94.29%,明显高于各指标的单项检测(77.14%、74.29%、77.14%)(P <0.05)。B 组联合检测 AUC 值最高,为0.963,明显高于 Cy-sC、Hcy 和 U-mAlb 单项检测的 AUC 值(P <0.05)。结论联合检测 CysC、Hcy 和 U-mAlb 可以显著提高早期诊断的敏感度,有利于 DN 的早期诊断和治疗,值得临床推广应用。
目的:探討血清胱抑素(Cystatin,CysC)、同型半胱氨痠(Homocysteine,Hcy)和尿微量清蛋白(Urinary mi-croalbuminuria,U-mAlb)聯閤檢測在早期糖尿病腎病(Early diabetic nephropathy,DN)診斷中的臨床應用。方法選擇112例糖尿病患者,根據臨床診斷將其分為 DN 尿蛋白暘性組40例(A 組)、DN 尿蛋白陰性組35例(B 組)、糖尿病無腎損害組37例(C 組),同時選擇同期來醫院健康體檢的健康者40例作為對照(對照組),分彆測定3組對象血清CysC、Hcy 和 U-mAlb 水平,併進行統計學比較。結果A 組和 B 組 CysC、Hcy 和 U-mAlb 水平明顯高于 C 組和對照組(P <0.05),其中 A 組3項指標水平升高最為顯著(P <0.05)。A 組和 B 組的暘性檢齣率明顯高于 C 組和對照組(P <0.05),且暘性率隨著患者腎損害程度的加重而升高。B 組3項指標聯閤檢測的診斷暘性率為94.29%,明顯高于各指標的單項檢測(77.14%、74.29%、77.14%)(P <0.05)。B 組聯閤檢測 AUC 值最高,為0.963,明顯高于 Cy-sC、Hcy 和 U-mAlb 單項檢測的 AUC 值(P <0.05)。結論聯閤檢測 CysC、Hcy 和 U-mAlb 可以顯著提高早期診斷的敏感度,有利于 DN 的早期診斷和治療,值得臨床推廣應用。
목적:탐토혈청광억소(Cystatin,CysC)、동형반광안산(Homocysteine,Hcy)화뇨미량청단백(Urinary mi-croalbuminuria,U-mAlb)연합검측재조기당뇨병신병(Early diabetic nephropathy,DN)진단중적림상응용。방법선택112례당뇨병환자,근거림상진단장기분위 DN 뇨단백양성조40례(A 조)、DN 뇨단백음성조35례(B 조)、당뇨병무신손해조37례(C 조),동시선택동기래의원건강체검적건강자40례작위대조(대조조),분별측정3조대상혈청CysC、Hcy 화 U-mAlb 수평,병진행통계학비교。결과A 조화 B 조 CysC、Hcy 화 U-mAlb 수평명현고우 C 조화대조조(P <0.05),기중 A 조3항지표수평승고최위현저(P <0.05)。A 조화 B 조적양성검출솔명현고우 C 조화대조조(P <0.05),차양성솔수착환자신손해정도적가중이승고。B 조3항지표연합검측적진단양성솔위94.29%,명현고우각지표적단항검측(77.14%、74.29%、77.14%)(P <0.05)。B 조연합검측 AUC 치최고,위0.963,명현고우 Cy-sC、Hcy 화 U-mAlb 단항검측적 AUC 치(P <0.05)。결론연합검측 CysC、Hcy 화 U-mAlb 가이현저제고조기진단적민감도,유리우 DN 적조기진단화치료,치득림상추엄응용。
Objective To study diagnostic value of Cystatin (CysC),Homocysteine (Hcy)and Urinary microalbu-minuria (U-mAlb)cinjoined detection for early diabetic nephropathy (DN).Methods 102 cases with diabetic were choosed.According to the clinical diagnosis,they were divided into DN urine protein Positive group with 40 cases (group A),DN urine protein negative group with 35 cases (group B),diabetic without kidney damage group with 37 ca-ses (group C),and 40 healthy cases as control(control group).CysC,Hcy and U-mAlb levels in serum were measured in three groups,were statistically compared.Results CysC,Hcy and U-mAlb levels of group A and group B were sig-nificantly higher than in group C and the control group (P < 0.05).And that of group A was the most significant (P <0.05).The diagnostic positive rate of group A and group B were significantly higher than that of group C and the con-trol group (P <0.05),and the positive rate increased with rise of the degree of renal damage in patients.The positive diagnostic rate of combined detection of group B was 94.29%,was significantly higher than 77.14%,74.29%,77.14%of single detection of each index(P <0.05).The value of AUC of combined detection was 0.963,was significantly high-er than single detection (P <0.05).Conclusion The combined detection of CysC,Hcy and U-mAlb significantly in-creased the diagnostic sensitivity,is worthy of clinical promotion.