CAJ | 학술논문

骨转换生化标志物具有灵敏性高、特异性强、稳定性好等优点，较骨密度更早反映出骨量变化，联合检测骨转换生化标志物，对评估骨形成和骨吸收的平衡状态、骨代谢疾病的鉴别诊断、抗骨质疏松疗效等方面有重要意义。骨转换生化标志物在骨质疏松症的诊断及骨代谢相关疾病的鉴别诊断以及抗骨质疏松治疗疗效判断方面均有重要意义，目前BALP、P1NP、TRAP、CTX作为相对研究较广泛的骨转化标志物已被应用于临床，一些较新的骨转换标志物（如OPG、LP、Cat K等）是否能作为预测骨折风险、监测治疗疗效的指标仍需临床医师进一步研究，以使其发挥最大的价值。本文对骨形成生化标志物、骨吸收生化标志物的研究进展及其在临床中的应用进行了简单综述。
골전환생화표지물구유령민성고、특이성강、은정성호등우점，교골밀도경조반영출골량변화，연합검측골전환생화표지물，대평고골형성화골흡수적평형상태、골대사질병적감별진단、항골질소송료효등방면유중요의의。골전환생화표지물재골질소송증적진단급골대사상관질병적감별진단이급항골질소송치료료효판단방면균유중요의의，목전BALP、P1NP、TRAP、CTX작위상대연구교엄범적골전화표지물이피응용우림상，일사교신적골전환표지물（여OPG、LP、Cat K등）시부능작위예측골절풍험、감측치료료효적지표잉수림상의사진일보연구，이사기발휘최대적개치。본문대골형성생화표지물、골흡수생화표지물적연구진전급기재림상중적응용진행료간단종술。
With high sensitivity, strong specificity, and good stability, bone turnover markers can reflect the changes of bone mass much earlier than bone mineral density ( BMD) does.The detection of bone turnover markers has great significance of evaluating the equilibrium status of bone formation and bone resorption, differential diagnosis of the metabolic bone diseases, and the evaluation of the effect of anti-osteoporosis treatment.This paper reviews the research progress of bone formation markers, bone resorption markers, and their clinical application.So far, bone turnover markers, such as BALP, P1NP, TRAP, and CTX, have been widely studied and applied in the clinical work.Some novel bone turnover markers, including OPG, LP, and Cat K, need to be further studied, in order to confirm whether they are suitable for the prediction of fracture and the surveillance of the therapeutic effect.