CAJ | 학술논문

骨形成是一个涉及从间充质干细胞向成骨细胞分化的复杂发育过程，研究骨形成过程中的关键因子并阐明其作用的具体分子机制对骨代谢性疾病的治疗具有重要意义。 Osterix（ Osx）是迄今为止发现的唯一一个成骨细胞特异性转录因子，Osx只在骨组织细胞中表达，在干细胞向成骨细胞分化过程中起决定性作用，没有Oxs就没有骨形成和骨再生。 Osx的发现为整个骨形成领域的研究开启了新的窗口。基于Osx在骨形成过程中的重要地位，研究者们迫切希望开发出作用于Osx的合成代谢分子，这对骨代谢性疾病的治疗将起到革命性的进步，因此对Osx的上下游因子及信号通路之间具体作用机制的进一步研究和阐明显得尤其重要。笔者对其研究进展做一综述。
골형성시일개섭급종간충질간세포향성골세포분화적복잡발육과정，연구골형성과정중적관건인자병천명기작용적구체분자궤제대골대사성질병적치료구유중요의의。 Osterix（ Osx）시흘금위지발현적유일일개성골세포특이성전록인자，Osx지재골조직세포중표체，재간세포향성골세포분화과정중기결정성작용，몰유Oxs취몰유골형성화골재생。 Osx적발현위정개골형성영역적연구개계료신적창구。기우Osx재골형성과정중적중요지위，연구자문박절희망개발출작용우Osx적합성대사분자，저대골대사성질병적치료장기도혁명성적진보，인차대Osx적상하유인자급신호통로지간구체작용궤제적진일보연구화천명현득우기중요。필자대기연구진전주일종술。
Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells into osteoblasts.The researches on the key factors and the elucidation of their specific molecular mechanism in bone formation have great significance for the treatment of bone metabolic diseases.Osterix ( Osx ) is the only osteoblast-specific transcriptional factor identified so far.The expression of Osx is exclusively found in bone tissues, which plays a decisive role in the differentiation of mesenchymal stem cells into osteoblasts.Without Osx, there is no bone formation and bone regeneration.The discovery of Osx opens a new window to the whole research field of bone formation, giving us a more thorough understanding of the process of bone formation.So far, suspending the bone resorption is the main part in most treatments of bone metabolic diseases, which can suspend the progress of diseases.However, it cannot achieve a radical cure.Considering the importance of Osx in bone formation, researchers are eager to develop drugs affecting on Osx, which would bring a revolutionary progress in the treatment of bone metabolic diseases.So, further study and elucidation of the mechanism between the up-stream factors and down-stream factors in Osx signaling pathway are extremely important.