CAJ | 학술논문

目的：为了考察环吡酮胺阴道栓阴道粘膜用药的安全性。方法以家兔和豚鼠为观察对象，进行环吡酮胺阴道栓对家兔阴道粘膜刺激性试验和环吡酮胺阴道栓对豚鼠阴道粘膜过敏性试验。结果家兔完整阴道粘膜组和破损阴道粘膜组在连续7天接触受试药后，阴道粘膜均未见到异常分泌物，无充血、水肿和坏死等症状，病理检查，无炎症性细胞浸润和组织细胞坏死现象，表明环吡酮胺阴道栓对家兔完整阴道粘膜组和破损阴道粘膜组均无刺激性；豚鼠阴道粘膜接触环吡酮胺阴道栓致敏后14天激发，豚鼠阴道粘膜干净，未见异常分泌物，无充血、水肿。结论表明环吡酮胺阴道栓对豚鼠阴道粘膜无明显致敏。
목적：위료고찰배필동알음도전음도점막용약적안전성。방법이가토화돈서위관찰대상，진행배필동알음도전대가토음도점막자격성시험화배필동알음도전대돈서음도점막과민성시험。결과가토완정음도점막조화파손음도점막조재련속7천접촉수시약후，음도점막균미견도이상분비물，무충혈、수종화배사등증상，병리검사，무염증성세포침윤화조직세포배사현상，표명배필동알음도전대가토완정음도점막조화파손음도점막조균무자격성；돈서음도점막접촉배필동알음도전치민후14천격발，돈서음도점막간정，미견이상분비물，무충혈、수종。결론표명배필동알음도전대돈서음도점막무명현치민。
Objective To investigate drug safety of ciclopirox olamine pessary for vagina mucosa .Method An irritation test with ciclopirox olamine pessary to vaginal mucosa of rabbit and hypersusceptibility test with ciclopirox olamine pessary to vagina mucosa of guinea pigs are performed .Result After continuously administration of ciclopirox olamine pessary for 7 days,the integrate vagina mucosa group and damaged vagina mucosa group of rabbits show no symptom of abnormal discharge ,hyperaemi-a,edema,necrosis,etc,and inflammatory cell accumulation and histiocytic necrotizing are not found in pathological examination ,indicating that ciclopirox olamine pessary has no irritation to vagina mucosa of rabbit in the both groups .After continuously allergia of ciclopirox olamine pessary for 14 days,vagina mucosa of guinea pig is clean showing no abnormal discharge and hyperaemia,which indicates that vagina mucosa of guinea pig.Conclusion It shows no hypersusceptibility to ciclopirox olamine pessa-ry.