中国保健营养(下旬刊)
中國保健營養(下旬刊)
중국보건영양(하순간)
CHINA HEALTH CARE & NUTRITION
2014年
5期
2405-2406
,共2页
精索静脉曲张%热休克蛋白90α%生殖%大鼠
精索靜脈麯張%熱休剋蛋白90α%生殖%大鼠
정색정맥곡장%열휴극단백90α%생식%대서
Varicocele%Heat shock protein90α%Reproduction%Rat
目的:探讨精索静脉曲张后大鼠生殖功能的变化和睾丸中热休克蛋白90α( HSP90α)的表达变化及规律。方法将32只SD大鼠随机分成4组:对照组和3个精索静脉曲张组(造模成功后第1、3、6周)。分别测定各组大鼠的相应脏器指数,检测精子相关指标、睾丸中HSP90α的表达。结果精索静脉曲张后,大鼠附睾指数在1、3周时显著低于对照组;精子活力1、3、6周组显著低于对照组,精子畸形率在1周3周时间点明显高于对照组,而1、3周时间点精子存活率显著低于对照组,其他试验组与对照组相比无显著差异;1、3、6周组睾丸中HSP90α的表达均显著高于对照组( P<0.05)。结论精索静脉曲张可引起大鼠生殖系统损伤以及睾丸中HSP90α的高表达,提示HSP90α可能保护机体在静脉曲张状态下受到的损伤。
目的:探討精索靜脈麯張後大鼠生殖功能的變化和睪汍中熱休剋蛋白90α( HSP90α)的錶達變化及規律。方法將32隻SD大鼠隨機分成4組:對照組和3箇精索靜脈麯張組(造模成功後第1、3、6週)。分彆測定各組大鼠的相應髒器指數,檢測精子相關指標、睪汍中HSP90α的錶達。結果精索靜脈麯張後,大鼠附睪指數在1、3週時顯著低于對照組;精子活力1、3、6週組顯著低于對照組,精子畸形率在1週3週時間點明顯高于對照組,而1、3週時間點精子存活率顯著低于對照組,其他試驗組與對照組相比無顯著差異;1、3、6週組睪汍中HSP90α的錶達均顯著高于對照組( P<0.05)。結論精索靜脈麯張可引起大鼠生殖繫統損傷以及睪汍中HSP90α的高錶達,提示HSP90α可能保護機體在靜脈麯張狀態下受到的損傷。
목적:탐토정색정맥곡장후대서생식공능적변화화고환중열휴극단백90α( HSP90α)적표체변화급규률。방법장32지SD대서수궤분성4조:대조조화3개정색정맥곡장조(조모성공후제1、3、6주)。분별측정각조대서적상응장기지수,검측정자상관지표、고환중HSP90α적표체。결과정색정맥곡장후,대서부고지수재1、3주시현저저우대조조;정자활력1、3、6주조현저저우대조조,정자기형솔재1주3주시간점명현고우대조조,이1、3주시간점정자존활솔현저저우대조조,기타시험조여대조조상비무현저차이;1、3、6주조고환중HSP90α적표체균현저고우대조조( P<0.05)。결론정색정맥곡장가인기대서생식계통손상이급고환중HSP90α적고표체,제시HSP90α가능보호궤체재정맥곡장상태하수도적손상。
Objective To investigate the changes of reproductive function and Hsp 90αgene expression in reproductive system of rat with varicocele .Methods Healthy 32 SD rats were randomly divided into 4 groups:control group and 3 varicocele group(1,3 and 6w after varicocele).Organ index and HSP90αgene expression in testicle were determined.Result At 1 and3w the epididymis index was significantly lower than it in the control;sperm motility rate is significantly lower than the control group at 1,3w and 6w(P<0.05),Sperm deformity and morality rate were significantly higher than the control group at 1 and 3w(P <0.05).Gene expression of HSP 90αin testicle was significantly higher than those in the control group at1,3 and 6w group(P<0.05).Concluis on Varicocele resulted in the damage of reproductive system,and the increased expression of HSP90αgene in testicle.The increased expression of HSP90αgene may protect cells from varicocele damage.