医学影像学杂志
醫學影像學雜誌
의학영상학잡지
JOURNAL OF MEDICAL IMAGING
2014年
5期
693-698
,共6页
柯俊%尹岩%戚荣丰%胡晓蕾%段炼%冯波%向虎%龚启勇%卢光明%李凌江
柯俊%尹巖%慼榮豐%鬍曉蕾%段煉%馮波%嚮虎%龔啟勇%盧光明%李凌江
가준%윤암%척영봉%호효뢰%단련%풍파%향호%공계용%로광명%리릉강
创伤后应激障碍%效应连接%Granger因果分析%杏仁核
創傷後應激障礙%效應連接%Granger因果分析%杏仁覈
창상후응격장애%효응련접%Granger인과분석%행인핵
Posttraumatic stress disorder%Effective connectivity%Granger causality analysis%Amygdala
目的：探讨创伤后应激障碍（posttraumatic stress disorder ，PTSD）患者杏仁核与全脑其它脑区间效应连接的改变。方法对经历汶川大地震的57例PTSD患者及77例对照行静息状态下的功能磁共振扫描，采用Granger因果（granger causality ，GC）检验方法分析双侧杏仁核与全脑其它脑区间影响的因果关系，进行组间比较并计算患者的临床用 PTSD诊断量表（clinician-Administered PTSD Scale ，CAPS）评分和异常脑区GC平均值的相关性。结果与对照组相比，PTSD患者杏仁核对内侧额回、扣带回、额上回、额下回、颞上回、颞下回和壳核的影响减弱，对海马和海马旁回、楔叶、楔前叶、丘脑的影响增强；而内侧额回、额中回、颞上回、颞中回、岛叶和壳核对杏仁核的影响减弱，楔叶、楔前叶和海马旁回对杏仁核的影响增强。PTSD患者的CAPS评分与杏仁核对颞上回和颞下回，额中回对杏仁核的影响呈负相关；而与杏仁核对楔前叶的影响呈正相关。结论 PTSD患者杏仁核与全脑其它脑区间的效应连接存在广泛异常，且与患者的症状严重程度相关。
目的：探討創傷後應激障礙（posttraumatic stress disorder ，PTSD）患者杏仁覈與全腦其它腦區間效應連接的改變。方法對經歷汶川大地震的57例PTSD患者及77例對照行靜息狀態下的功能磁共振掃描，採用Granger因果（granger causality ，GC）檢驗方法分析雙側杏仁覈與全腦其它腦區間影響的因果關繫，進行組間比較併計算患者的臨床用 PTSD診斷量錶（clinician-Administered PTSD Scale ，CAPS）評分和異常腦區GC平均值的相關性。結果與對照組相比，PTSD患者杏仁覈對內側額迴、釦帶迴、額上迴、額下迴、顳上迴、顳下迴和殼覈的影響減弱，對海馬和海馬徬迴、楔葉、楔前葉、丘腦的影響增彊；而內側額迴、額中迴、顳上迴、顳中迴、島葉和殼覈對杏仁覈的影響減弱，楔葉、楔前葉和海馬徬迴對杏仁覈的影響增彊。PTSD患者的CAPS評分與杏仁覈對顳上迴和顳下迴，額中迴對杏仁覈的影響呈負相關；而與杏仁覈對楔前葉的影響呈正相關。結論 PTSD患者杏仁覈與全腦其它腦區間的效應連接存在廣汎異常，且與患者的癥狀嚴重程度相關。
목적：탐토창상후응격장애（posttraumatic stress disorder ，PTSD）환자행인핵여전뇌기타뇌구간효응련접적개변。방법대경력문천대지진적57례PTSD환자급77례대조행정식상태하적공능자공진소묘，채용Granger인과（granger causality ，GC）검험방법분석쌍측행인핵여전뇌기타뇌구간영향적인과관계，진행조간비교병계산환자적림상용 PTSD진단량표（clinician-Administered PTSD Scale ，CAPS）평분화이상뇌구GC평균치적상관성。결과여대조조상비，PTSD환자행인핵대내측액회、구대회、액상회、액하회、섭상회、섭하회화각핵적영향감약，대해마화해마방회、설협、설전협、구뇌적영향증강；이내측액회、액중회、섭상회、섭중회、도협화각핵대행인핵적영향감약，설협、설전협화해마방회대행인핵적영향증강。PTSD환자적CAPS평분여행인핵대섭상회화섭하회，액중회대행인핵적영향정부상관；이여행인핵대설전협적영향정정상관。결론 PTSD환자행인핵여전뇌기타뇌구간적효응련접존재엄범이상，차여환자적증상엄중정도상관。
Objective To explore the alteration of the effective connectivity between amygdala and other brain regions in posttraumatic stress disorder (PTSD) patients .Methods Fifty-seven patients with PTSD and seventy-seven controls who survived from the Wenchuan earthquake underwent the resting-state functional magnetic imaging scan .Granger causality analysis was used to compare the effective connectivity network of amygdala between PTSD patients and controls .In addi-tion ,Pearson correlation was performed between abnormal Granger causality and the Clinician-Administered PTSD Scale (CAPS) score of patients .Results Compared with controls ,PTSD patients showed decreased influence from amygdala to medial frontal gyrus ,cingulate cortex ,superior and inferior frontal gyri ,superior and inferior temporal gyri ,putmen ,and inceased influence from amygdala to hippocampus ,parahipocampal gyrus ,cuneus ,precuneus and thalama .Furthermore ,PTSD patients exhibited decreased influence from medial and middle frontal gyri ,superior and middle temporal gyri ,insu-lar ,putamen to amygdala ,and increased influence from cuneus ,precuneus and parahippocampal gyrus to amygdala .The CAPS score was negatively correlated with effective connectivity from amygdala to superior and inferior temporal gyri , from middle frontal gyrus to amygdala ,and positively correlated with effective connectivity from amgdala to precuneus . Conclusion The effective connectivity network of amygdala is widespreadly disrupted in PTSD patients ,and is partly cor-related with their disease severity .
