CAJ | 학술논문

目的探讨发疹性微静脉血管瘤(eruptive microvenular hemangioma,EMVH)的临床及组织病理学特征.方法回顾性分析6例患者的临床及病理资料.结果 6例患者均为中青年,平均发病年龄34岁,男女比例均等；特征皮损为突然发生、泛发全身的红褐色丘疹和结节,直径0.1～2.0 cm,无自觉症状.组织病理学显示:真皮内增生的胶原纤维束间广泛的分枝状、薄壁小血管增生,界限不清,部分管腔闭塞.血管内皮细胞无异形.免疫组化示:血管内皮细胞CD34、CD31和第八因子相关抗原(F-Ⅷ)阳性.结论首次提出了发疹性微静脉血管瘤的诊断,认识该病有助于早期诊断并避免不必要的治疗.
목적 탐토발진성미정맥혈관류(eruptive microvenular hemangioma,EMVH)적림상급조직병이학특정.방법 회고성분석6례환자적림상급병리자료.결과 6례환자균위중청년,평균발병년령34세,남녀비례균등；특정피손위돌연발생、범발전신적홍갈색구진화결절,직경0.1～2.0 cm,무자각증상.조직병이학현시:진피내증생적효원섬유속간엄범적분지상、박벽소혈관증생,계한불청,부분관강폐새.혈관내피세포무이형.면역조화시:혈관내피세포CD34、CD31화제팔인자상관항원(F-Ⅷ)양성.결론 수차제출료발진성미정맥혈관류적진단,인식해병유조우조기진단병피면불필요적치료.
Objective To analyze the clinical and histopathologic features of eruptive microvenular hemangioma (EMVH). Methods The clinical and histological findings in six patients with EMVH were retrospectively reviewed.Results The patients were young or middle-aged,with a median age of onset of 34 years.The ratio of males to females was 1 ∶ 1.Clinically,all the patients experienced a sudden development of widespread,asymptomatic,brunneus,flat-topped papules and plaques measuring from 0.1 to 2.0 cm in diameter.Histopathologic examination revealed a poorly circumscribed proliferation of small,irregularly branched,thin-walled blood vessels haphazardly arranged between collagen fiber bundles in the dermis.The lumina of the blood vessels were often collapsed.There was no cellular atypia or mitosis.A variable degree of sclerosis was noted in the surrounding stroma.Immunobistochemical study revealed that the endothelial cells stained positive for CD34,CD31,and factor Ⅷ-related antigen.Conclusions The diagnosis of EMVH is proposed,and awareness of this disease may benefit its early diagnosis and avoidance of unnecessary treatment.