CAJ | 학술논문

人垂体瘤转化基因（ hPTTG）是一种潜在的癌基因，自发现以来一直是研究的热点，在人体肿瘤中主要表达hPTTG1，且在多种肿瘤中高表达。研究证实，hPTTG1具有促进细胞转化、血管生成及肿瘤转移等生物学功能，在肿瘤的发生、发展、侵袭、转移及复发中起重要作用。 hPTTG1对肿瘤的诊断具有重要的参考价值，有望成为肿瘤基因治疗的新靶点。
인수체류전화기인（ hPTTG）시일충잠재적암기인，자발현이래일직시연구적열점，재인체종류중주요표체hPTTG1，차재다충종류중고표체。연구증실，hPTTG1구유촉진세포전화、혈관생성급종류전이등생물학공능，재종류적발생、발전、침습、전이급복발중기중요작용。 hPTTG1대종류적진단구유중요적삼고개치，유망성위종류기인치료적신파점。
As a potential oncogene, human pituitary tumor transforming gene( hPTTG) has been always the research foucs since it was discovered. hPTTG1 is mainly expressed in human tumors and highly expressed in a variety of tumors. Related studies have shown that hPTTG1 has the function of promoting cell transformation, angiogenesis, tumor metastasis and other biological functions. Be-sides, it plays an important role in tumorigenesis,occurrence,development,invasion, metastasis and recurrence of tumors. hPTTG1 has important reference value for diagnosis of tumor, and it represents potential target for gene therapy of tumor.