临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
5期
465-468
,共4页
胃肠间质瘤%分子靶向治疗%手术切除
胃腸間質瘤%分子靶嚮治療%手術切除
위장간질류%분자파향치료%수술절제
Gastrointestinal stromal tumor( GIST)%Molecular targeted therapy%Surgical resection
作为胃肠道最常见的一类间叶源性肿瘤，胃肠间质瘤（ GIST）越来越受到关注。近10年来，随着对GIST分子机制研究的深入，以伊马替尼为代表的分子靶向药物的出现，改变了GIST的传统治疗理念，形成了外科手术联合分子靶向药物的治疗模式。靶向药物在GIST的术前、术后辅助治疗及晚期GIST中的应用显著改善了患者的预后，延长了生存时间。但是，针对不同期别的GIST，应该如何合理应用这些靶向药物，临床还有很多问题亟待解决。本文就GIST的围手术期治疗及晚期GIST治疗的最新进展作一综述。
作為胃腸道最常見的一類間葉源性腫瘤，胃腸間質瘤（ GIST）越來越受到關註。近10年來，隨著對GIST分子機製研究的深入，以伊馬替尼為代錶的分子靶嚮藥物的齣現，改變瞭GIST的傳統治療理唸，形成瞭外科手術聯閤分子靶嚮藥物的治療模式。靶嚮藥物在GIST的術前、術後輔助治療及晚期GIST中的應用顯著改善瞭患者的預後，延長瞭生存時間。但是，針對不同期彆的GIST，應該如何閤理應用這些靶嚮藥物，臨床還有很多問題亟待解決。本文就GIST的圍手術期治療及晚期GIST治療的最新進展作一綜述。
작위위장도최상견적일류간협원성종류，위장간질류（ GIST）월래월수도관주。근10년래，수착대GIST분자궤제연구적심입，이이마체니위대표적분자파향약물적출현，개변료GIST적전통치료이념，형성료외과수술연합분자파향약물적치료모식。파향약물재GIST적술전、술후보조치료급만기GIST중적응용현저개선료환자적예후，연장료생존시간。단시，침대불동기별적GIST，응해여하합리응용저사파향약물，림상환유흔다문제극대해결。본문취GIST적위수술기치료급만기GIST치료적최신진전작일종술。
As the most common mesenchymal tumor of gastrointestinal tract,gastrointestinal stromal tumor( GIST) has been paid more and more attention. In the recent 10 years,with studies on molecular mechanism of GIST,and emergence of molecular targe-ted drugs represented by imatinib mesylate,traditional treatment concepts of GIST have been updated. Surgical resection combined with molecular targeted drugs is becoming the treatment mode for GIST. Molecular targeted therapy has significantly improved the prognosis and prolong the survival of GIST patients. However, for different stages of GIST,many questions on how to apply the targeted drugs rea-sonably still remain to be answered. This article summarizes the latest progress on the perioperative treatment of GIST and systemic ther-apy for advanced GIST.
