CAJ | 학술논문

目的：探讨影响Siewert Ⅱ、Ⅲ型贲门癌患者预后的影响因素。方法收集2000年4月至2012年4月接受手术治疗的92例贲门癌患者的临床资料并随访患者生存情况，影响5年生存率及总生存期（ OS）的因素。结果截止2012年9月1日，92例患者共死亡53例，5年生存率为27?4％，中位OS为36?0个月。 Siewert分型、T分期、N分期和UICC分期是贲门癌5年生存率的影响因素，但与年龄、病理类型、Lauren分型、手术方式及淋巴结清扫方式均无关（ P＞0?05）。 Cox多因素分析显示，T分期、N分期是影响Siewert Ⅱ、Ⅲ型贲门癌预后的独立因素。结论 T分期、N分期是影响贲门癌预后的独立因素；Siewert分型因素的影响作用尚具有不确定性，但对贲门癌手术方式的选择具有指导意义。
목적：탐토영향Siewert Ⅱ、Ⅲ형분문암환자예후적영향인소。방법수집2000년4월지2012년4월접수수술치료적92례분문암환자적림상자료병수방환자생존정황，영향5년생존솔급총생존기（ OS）적인소。결과절지2012년9월1일，92례환자공사망53례，5년생존솔위27?4％，중위OS위36?0개월。 Siewert분형、T분기、N분기화UICC분기시분문암5년생존솔적영향인소，단여년령、병리류형、Lauren분형、수술방식급림파결청소방식균무관（ P＞0?05）。 Cox다인소분석현시，T분기、N분기시영향Siewert Ⅱ、Ⅲ형분문암예후적독립인소。결론 T분기、N분기시영향분문암예후적독립인소；Siewert분형인소적영향작용상구유불학정성，단대분문암수술방식적선택구유지도의의。
Objective To explore the prognostic factors in 92 patients with SiewertⅡandⅢtype of cardia cancer. Methods Ninety-two patients with Siewert Ⅱ and Ⅲ type of cardia cancer admitted by our hospital from April 2000 to April 2012 were en-rolled. The clinical data were collected and the patients were followed up for the 5-year survival rate and median overall survival( OS) . The univariate analysis and Cox regression hazard model analysis were used to analyze the factors affecting the prognosis for SiewertⅡandⅢtype of cardia cancer. Results At the end of the follow-up period( September 1, 2012) , 53 out of 92 patients died with the 5-year survival rate of 27?4% and the median OS of 36?0 months. There were significant differences on 5-year survival rates between dif-ferent Siewert type, T stage, N stage and UICC staging(P<0?05). The 5-year survival rates were unrelated to age, histopathology, Lauren type, lymph node dissection and surgical approach. T stage and N stage were independent factors affecting the prognosis for Siewert Ⅱ,Ⅲtype of cardia cancer. Conclusion T stage and N stage were the independent factors affecting the cardia cancer of gas-troesophageal junction. Siewert type can provide useful information for determining the appropriate surgery.