CAJ | 학술논문

研究颅骨超声治疗声压和温度预测问题,高强度聚焦超声( high-intensity focused ultrasound, HIFU)经颅脑肿瘤治疗中,由于在颅骨处可能形成声压和温度较高的热点,引起颅骨及周边组织损伤。为解决上述问题,利用Westervelt声传播方程近似式及Pennes生物热传导方程,以凹球面八圆环相控换能器和人体头颅CT数据建立的仿真模型为例,结合时间反转法,分析讨论经颅HIFU形成的声压场和温度场。研究结果表明,降低热点声压及温升的同时可实现在颅内目标靶区中聚焦；在该数值仿真模型中,在凹球面八圆环相控换能器的一维可变焦范围内均可实现颅内聚焦和颅骨热点处声压和温升的降低。
연구로골초성치료성압화온도예측문제,고강도취초초성( high-intensity focused ultrasound, HIFU)경로뇌종류치료중,유우재로골처가능형성성압화온도교고적열점,인기로골급주변조직손상。위해결상술문제,이용Westervelt성전파방정근사식급Pennes생물열전도방정,이요구면팔원배상공환능기화인체두로CT수거건립적방진모형위례,결합시간반전법,분석토론경로HIFU형성적성압장화온도장。연구결과표명,강저열점성압급온승적동시가실현재로내목표파구중취초；재해수치방진모형중,재요구면팔원배상공환능기적일유가변초범위내균가실현로내취초화로골열점처성압화온승적강저。
During the transcranial therapy by using high-intensity focused ultrasound ( HIFU) , the hot spot with a peak acoustic pressure and a high temperature rise might be induced on the skull, which can injure the skull and the surrounding tissue. In this paper, the approximation of the Westervelt formula and Pennes bio-heat conduction e-quation were applied to the simulation model which was based on spherical eight annular phased array transducer and CT data of a human skull and combined with time reversal method in order to analyze and discuss the acoustic pres-sure and temperature distribution of transcranial HIFU. The results show that, when the acoustic pressure and temper-ature of the hot spot in skull were reduced, it can focus at the target region through the skull. In this simulation mod-el, it reduced the acoustic pressure and temperature of hot spot in the one-dimensional focusing range of the spherical eight annular phased array transducer.