CAJ | 학술논문

　　自身抗体是指抗自身细胞内、细胞表面和细胞外抗原的免疫球蛋白，是自身免疫和自身免疫性疾病重要特征之一。抗核抗体是指抗细胞内所有抗原成分的自身抗体的总称，某些自身免疫性疾病伴有特征性的自身抗体谱，而疾病标记性抗体或特异性抗体可诊断和鉴别诊断疾病特性。自身抗体可判断疾病的活动性及预后，观察治疗反应，指导临床治疗。进一步的抗核抗体谱研究，可阐明抗核抗体与自身免疫性疾病的相关性。该文对抗核抗体谱及其靶抗原与疾病的相关性进行了综述。
　　자신항체시지항자신세포내、세포표면화세포외항원적면역구단백，시자신면역화자신면역성질병중요특정지일。항핵항체시지항세포내소유항원성분적자신항체적총칭，모사자신면역성질병반유특정성적자신항체보，이질병표기성항체혹특이성항체가진단화감별진단질병특성。자신항체가판단질병적활동성급예후，관찰치료반응，지도림상치료。진일보적항핵항체보연구，가천명항핵항체여자신면역성질병적상관성。해문대항핵항체보급기파항원여질병적상관성진행료종술。
Autoantibodies refer to the resistance of immune globulins to their own intracellular antigens , the cell surface antigen and the extracellular antigen;They are one of the key characteristics for autoimmune and autoim-mune diseases .Antinuclear antibodies are the total autoantibodies of intracellular antigenic components .Some auto-immune diseases contain characteristic autoantibodies .The marked autoantibodies or special autoantibodies can be used for diagnosis and differential diagnosis of the disease characters .Autoantibodies can be estimated for activity and prognosis of diseases , responsed to therapies , and guided for clinic treatment as well .Further antinuclear antibody spectrum research can clarify the relationship between the antinuclear antibodies and autoimmune diseases .Thus, this paper clarifies the relationship between antinuclear antibody , auto antigen and diseases .