CAJ | 학술논문

　　目的研究骨性关节炎(osteoarthritis，OA)患者关节滑液中结合珠蛋白(haptoblobin，Hp)水平与病情严重程度的相关性，探讨Hp在OA病理过程中的作用机制。方法收集2011年7月-2012年2月在解放军总医院行关节镜诊治的41例OA患者及18例非OA膝关节疾病患者(半月板损伤16例，盘状半月板2例，均无明显关节软骨损伤)关节滑液，采用Outerbridge软骨损伤评分法对OA患者分级并记录OA患者膝关节HSS评分(美国特种外科医院膝关节评分)。采用酶联免疫吸附试验(ELISA)检测两组关节滑液中Hp水平。比较不同程度OA患者滑液Hp水平。结果 OA组滑液中Hp水平明显高于非OA组[(23.04±13.19)μg/mlvs (7.32±3.76)μg/ml，P＜0.001]。OA组滑液中Hp水平与膝关节HSS评分呈负相关(r=-0.487，P=0.001)。结论滑液中Hp水平与OA病变严重程度呈正相关，测定OA患者滑液中Hp水平对早期诊断和有效防治具有重要意义。
　　목적연구골성관절염(osteoarthritis，OA)환자관절활액중결합주단백(haptoblobin，Hp)수평여병정엄중정도적상관성，탐토Hp재OA병리과정중적작용궤제。방법수집2011년7월-2012년2월재해방군총의원행관절경진치적41례OA환자급18례비OA슬관절질병환자(반월판손상16례，반상반월판2례，균무명현관절연골손상)관절활액，채용Outerbridge연골손상평분법대OA환자분급병기록OA환자슬관절HSS평분(미국특충외과의원슬관절평분)。채용매련면역흡부시험(ELISA)검측량조관절활액중Hp수평。비교불동정도OA환자활액Hp수평。결과 OA조활액중Hp수평명현고우비OA조[(23.04±13.19)μg/mlvs (7.32±3.76)μg/ml，P＜0.001]。OA조활액중Hp수평여슬관절HSS평분정부상관(r=-0.487，P=0.001)。결론활액중Hp수평여OA병변엄중정도정정상관，측정OA환자활액중Hp수평대조기진단화유효방치구유중요의의。
Objective To study the correlation between haptoblobin (Hp) level in synovial fluid (SF) and severity of osteoarthritis (OA) and the mechanism of Hp underlying the pathogenesis of OA. Methods Forty-one arthroscopy-confirmed knee OA patients and 18 non-OA patients (16 with meniscus injury and 2 with discoid meniscus but without significant cartilage injury) admitted to our hospital from July 2011 to February 2012 were included in this study. Their SF was collected. The OA patients were classified according to the Outerbridge cartilage scoring scale and their HSS knee scores were recorded. Hp levels in SF were measured by ELISA and compared in OA patients at different severity. Results The Hp level in SF was significantly higher in OA patients than in non-OA patients (23.04±13.19μg/ml vs 7.32±3.76μg/ml, P<0.001) and negatively correlated with the knee HSS score in OA patients (r=-0.768, P<0.001). Conclusion Hp level in SF is positively correlated with the severity of OA. Measurement of Hp level in SF is of great importance for the early diagnosis and effective prevention and treatment of OA.