CAJ | 학술논문

【目的】探讨原发性高血压（EH）患者血清肿瘤坏死因子-a（TNF-α）、核转录因子-κB（NF-κB）水平变化及其临床意义。【方法】选择分级为Ⅰ、Ⅱ、Ⅲ级的E H患者各30例，并以30例健康者为对照，用酶联免疫吸附测定法（ELISA）检测血清中TNF-α、NF-κB水平。【结果】EH组血清 TNF-α、NF-κB水平明显高于正常组（ P ＜0．01）；EH不同级间患者血清TNF-α、NF-κB水平均有统计学差异（ P ＜0．05或 P ＜0．01），且随病情加重而升高。EH 组及 EH 不同级组 TNF-α水平与 NF-κB水平间均呈正相关（ P ＜0．05）。【结论】TNF-α、NF-κB可能参与EH的发生与进展，监测血清TNF-α、NF-κB水平可作为判断EH病情的指标。
【목적】탐토원발성고혈압（EH）환자혈청종류배사인자-a（TNF-α）、핵전록인자-κB（NF-κB）수평변화급기림상의의。【방법】선택분급위Ⅰ、Ⅱ、Ⅲ급적E H환자각30례，병이30례건강자위대조，용매련면역흡부측정법（ELISA）검측혈청중TNF-α、NF-κB수평。【결과】EH조혈청 TNF-α、NF-κB수평명현고우정상조（ P ＜0．01）；EH불동급간환자혈청TNF-α、NF-κB수평균유통계학차이（ P ＜0．05혹 P ＜0．01），차수병정가중이승고。EH 조급 EH 불동급조 TNF-α수평여 NF-κB수평간균정정상관（ P ＜0．05）。【결론】TNF-α、NF-κB가능삼여EH적발생여진전，감측혈청TNF-α、NF-κB수평가작위판단EH병정적지표。
[Objective]To explore the changes and clinical significance of serum tumor necrosis factor-α(TNF-α) and nuclear factor-κB(NF-κB) in patients with essential hypertension (EH) .[Methods] Patients with gradeⅠ( n=30) ,Ⅱ(n=30) and Ⅲ( n=30) EH were selected .Other 30 healthy patients were selected as the controls .Enzyme-linked immunosorbent assay (ELISA) was used to detect serum levels of TNF-αand NF-κB .[Results]Serum levels of TNF-αand NF-κB in EH group were obviously higher than those in normal group ( P<0 .01) .There was significant difference in serum levels of TNF-αand NF-κB among patients with different grade of EH ( P<0 .05 or P<0 .01) . Serum levels of TNF-αand NF-κB increased with the exacerbation of EH .Serum levels of TNF-αin EH group and EH groups with different grade were positively correlated with NF-κB( P<0 .05) .[Conclusion] TNF-αand NF-κB may be involved in the incidence and progress of EH .The monitoring of serum TNF-αand NF-κB levels can be used as the indicators for assessing the condition of EH .