CAJ | 학술논문

目的：探讨核转录因子（ NF-κB）在卵巢浆液性囊腺癌组织中的表达和临床意义。方法卵巢浆液性囊腺癌41例，卵巢浆液性囊腺瘤30例，正常卵巢组织30例，采用免疫组织化学法检测组织中NF-κB蛋白表达情况。结果 NF-κB蛋白在正常卵巢组织中无表达，卵巢浆液性囊腺癌组阳性表达率（70．7％）高于卵巢浆液性囊性瘤组（20．0％）（P＜0．001）；组织学分级为中低分化组、病理临床分期为Ⅲ～Ⅳ期组、有淋巴转移及CA125≥500 U／L组的NF-κB蛋白阳性表达率较高（ P＜0．05）。结论 NF-κB在卵巢癌的发生发展中起重要作用。
목적：탐토핵전록인자（ NF-κB）재란소장액성낭선암조직중적표체화림상의의。방법란소장액성낭선암41례，란소장액성낭선류30례，정상란소조직30례，채용면역조직화학법검측조직중NF-κB단백표체정황。결과 NF-κB단백재정상란소조직중무표체，란소장액성낭선암조양성표체솔（70．7％）고우란소장액성낭성류조（20．0％）（P＜0．001）；조직학분급위중저분화조、병리림상분기위Ⅲ～Ⅳ기조、유림파전이급CA125≥500 U／L조적NF-κB단백양성표체솔교고（ P＜0．05）。결론 NF-κB재란소암적발생발전중기중요작용。
Objective To investigate the expression and clinical significance of nuclear factor -κB( NF-κB) in ovarian serous cystadenocarcinoma .Methods Immunohistochemical method was used to detect the expression of NF -κB protein in 41 cases of ovarian serous cystadenocarcinoma ,30 cases of ovarian serous cystic adenoma and 30 cases of normal ovarian tissue .Results No expression of NF-κB protein was detected in normal ovarian tissue ,the positive rate of NF-κB in ovarian serous cystadenocarcinoma was significantly higher than that in ovarian serous cystic adenoma (70.7%vs.20.0%,P<0.001).The expression of NF-κB protein was higher in patients with poor differentiation , clinical stage Ⅲ-Ⅳ,positive lymph nodes metastasis and CA 125≥500 U/L(P<0.05).Conclusion NF-κB plays an important role in the development of ovarian cancer .