贵州医药
貴州醫藥
귀주의약
GUIZHOU MEDICAL JOURNAL
2014年
5期
391-393
,共3页
哮喘儿童%呼出气一氧化氮%外周血嗜酸性粒细胞
哮喘兒童%呼齣氣一氧化氮%外週血嗜痠性粒細胞
효천인동%호출기일양화담%외주혈기산성립세포
Aasthmatic children%Exhaled nitric oxide%Peripheral blood eosinophils
目的：探讨哮喘儿童治疗前后呼出气一氧化氮（FENO ）变化及与肺功能、外周血嗜酸性粒细胞（EOS ）关系的临床研究。方法选取2012年9月至2013年6月于贵州省人民医院哮喘门诊就诊的初治哮喘患儿40例，年龄5～12岁（未系统治疗，近一月未使用激素及其他药物如孟鲁司特钠、氨茶碱等），20例哮喘急性发作期，20例哮喘非急性发作期，分别测定FENO、肺功能、外周血EOS计数。经沙美特罗替卡松治疗1月后 FENO、肺功能的复测。选取15例正常同龄儿童（无哮喘、鼻炎、过敏史，近2周无呼吸道感染史）FENO、外周血EOS计数、肺功能作为对照，分析治疗前后FENO的变化及其与肺功能 FEV 1％、外周血 EOS 计数的相关性。结果哮喘儿童急性发作期 FENO （44．86±16．88） ppb ，非急性发作期FENO （33．35±16．88） ppb ，均高于正常儿童，急性发作组高于非急性发作组，但FENO与肺功能无明显相关性，亦与外周血EOS无明显相关性，治疗后 FENO明显降低。结论 FENO在哮喘管理中需与肺功能、外周血嗜酸性粒细胞等指标联合应用。
目的：探討哮喘兒童治療前後呼齣氣一氧化氮（FENO ）變化及與肺功能、外週血嗜痠性粒細胞（EOS ）關繫的臨床研究。方法選取2012年9月至2013年6月于貴州省人民醫院哮喘門診就診的初治哮喘患兒40例，年齡5～12歲（未繫統治療，近一月未使用激素及其他藥物如孟魯司特鈉、氨茶堿等），20例哮喘急性髮作期，20例哮喘非急性髮作期，分彆測定FENO、肺功能、外週血EOS計數。經沙美特囉替卡鬆治療1月後 FENO、肺功能的複測。選取15例正常同齡兒童（無哮喘、鼻炎、過敏史，近2週無呼吸道感染史）FENO、外週血EOS計數、肺功能作為對照，分析治療前後FENO的變化及其與肺功能 FEV 1％、外週血 EOS 計數的相關性。結果哮喘兒童急性髮作期 FENO （44．86±16．88） ppb ，非急性髮作期FENO （33．35±16．88） ppb ，均高于正常兒童，急性髮作組高于非急性髮作組，但FENO與肺功能無明顯相關性，亦與外週血EOS無明顯相關性，治療後 FENO明顯降低。結論 FENO在哮喘管理中需與肺功能、外週血嗜痠性粒細胞等指標聯閤應用。
목적：탐토효천인동치료전후호출기일양화담（FENO ）변화급여폐공능、외주혈기산성립세포（EOS ）관계적림상연구。방법선취2012년9월지2013년6월우귀주성인민의원효천문진취진적초치효천환인40례，년령5～12세（미계통치료，근일월미사용격소급기타약물여맹로사특납、안다감등），20례효천급성발작기，20례효천비급성발작기，분별측정FENO、폐공능、외주혈EOS계수。경사미특라체잡송치료1월후 FENO、폐공능적복측。선취15례정상동령인동（무효천、비염、과민사，근2주무호흡도감염사）FENO、외주혈EOS계수、폐공능작위대조，분석치료전후FENO적변화급기여폐공능 FEV 1％、외주혈 EOS 계수적상관성。결과효천인동급성발작기 FENO （44．86±16．88） ppb ，비급성발작기FENO （33．35±16．88） ppb ，균고우정상인동，급성발작조고우비급성발작조，단FENO여폐공능무명현상관성，역여외주혈EOS무명현상관성，치료후 FENO명현강저。결론 FENO재효천관리중수여폐공능、외주혈기산성립세포등지표연합응용。
Objective To find out changes the exhaled nitric oxide (FENO) in asthmatic children before and after treatment and the relationship of FENO with lung function and peripheral blood eosin-ophils (EOS) .Methods A total of 40 children which were 20 cases of acute asthma exacerbation ,20 cases of non-acute asthma exacerbation ,and aged 5-12 years old that had not received any systematic treatment ,had not used any hormone or other drugs such as Montelukast Sodium and aminophylline , etc .within one month with newly diagnosed asthma from September 2012 to June 2013 in the Guizhou Provincial People's Hospital's asthma clinic were included in the studies .Their FENO ,lung function , peripheral blood EOS counts were measured respectively .After one month's treatment with Salmeterol fluticasone propionate ,FENO ,lung function were reexamined and measured again .FENO ,peripheral blood EOS counts and pulmonary function of 15 normal children with the same age which were no asthma ,rhinitis ,allergies history ,no respiratory infections history within two weeks were treated as control group .Analyzed the FENO changes ,and its correlation between lung function FEV1% and peripheral EOS count before and after treatment .Results Children with acute asthma exacerbation , FENO were (44 .86 ± 16 .88)ppb .Children with non-acute asthma exacerbation ,FENO were (33 .35 ± 16 .88)ppb .Both were higher than that in normal children ,acute exacerbation group had much higher value than that in the non-acute exacerbation group .However ,there was no significant correla-tion between FENO and lung function or peripheral blood EOS .FENO was significantly reduced after treatment .Conclusion FENO in asthma treatment management requires being in joint use with lung function and peripheral blood eosinophils and other indicators .
