CAJ | 학술논문

从薯蓣皂苷元（Diosgenin，Dio）抗肿瘤作用、抗肿瘤作用机制方面综述近十年来国内外薯蓣皂苷元抗肿瘤作用及其机制研究进展，指出薯蓣皂苷元是一种天然的甾体皂苷，其来源广泛，具有调节免疫、抗肿瘤、抗炎等多种药理活性，其抗肿瘤活性引起了广大学者的关注，作用机制具有多靶点、多环节、多效应的特点，同时指出Dio对不同类型的肿瘤作用机制各有不同，研究深度各有差异，因此有必要利用现代分子生物技术对Dio在不同肿瘤中的作用及机制进行更全面更深入的研究；同时，针对Dio的抗肿瘤作用特点，联合其他抗肿瘤药物进行研究，将能更充分发挥传统中药在抗肿瘤方面的独特效用。
종서여조감원（Diosgenin，Dio）항종류작용、항종류작용궤제방면종술근십년래국내외서여조감원항종류작용급기궤제연구진전，지출서여조감원시일충천연적치체조감，기래원엄범，구유조절면역、항종류、항염등다충약리활성，기항종류활성인기료엄대학자적관주，작용궤제구유다파점、다배절、다효응적특점，동시지출Dio대불동류형적종류작용궤제각유불동，연구심도각유차이，인차유필요이용현대분자생물기술대Dio재불동종류중적작용급궤제진행경전면경심입적연구；동시，침대Dio적항종류작용특점，연합기타항종류약물진행연구，장능경충분발휘전통중약재항종류방면적독특효용。
The paper is discussing the progress of anti-tumor effects and its mechanism of diosgenin (Dio) in recent ten years at home and abroad from the anti-tumor effects and its mechanism. Dio is a kind of natural steroidal saponin, and widely available, it shows pharmacological activities such as immunity-regulating, anti-tumor, anti-in-flammation, the anti-tumor activity had attracted the attention of many scholars, its mechanism demonstrates the fea-tures of multiple target points, multiple links and multiple effects, at the same time, the mechanisms of Dio fighting against different types of tumors are different, and their depths are different, therefore, it is necessary to study the ef-fects and its mechanisms completely with modern molecular biology; meanwhile, the studies centered on anti-tumor features of Dio and the combination with other anti-tumor drugs could fully develop the unique roles of traditional herbs fighting against the tumor.