CAJ | 학술논문

目的：研究脑卒中后抑郁症患者的海马形状变化，并探讨其意义。方法：选取22例脑卒中后抑郁症（PSD）患者（病例组）及29例健康对照者（对照组），使用计算机自动分割和顶点分析技术，获得两组的校正后海马体积和海马表面模型，进行体积和形状的组间比较。结果：体积比较显示两组之间的左右侧海马体积差异均无统计学意义（左侧P 值＝0．60，右侧P值＝0．09），形状分析显示病例组的双侧海马局部区域较对照组存在萎缩，以左侧海马体部腹侧最为明显。结论：PSD患者的海马存在容易被常规体积测量方法所忽略的形状改变，对形状进行研究可能有助于疾病的早期诊断、鉴别和探讨疾病间的潜在联系。
목적：연구뇌졸중후억욱증환자적해마형상변화，병탐토기의의。방법：선취22례뇌졸중후억욱증（PSD）환자（병례조）급29례건강대조자（대조조），사용계산궤자동분할화정점분석기술，획득량조적교정후해마체적화해마표면모형，진행체적화형상적조간비교。결과：체적비교현시량조지간적좌우측해마체적차이균무통계학의의（좌측P 치＝0．60，우측P치＝0．09），형상분석현시병례조적쌍측해마국부구역교대조조존재위축，이좌측해마체부복측최위명현。결론：PSD환자적해마존재용역피상규체적측량방법소홀략적형상개변，대형상진행연구가능유조우질병적조기진단、감별화탐토질병간적잠재련계。
Objective:To study the hippocampus morphology of patients with post-stroke depression.Methods:The volume after correction and the surface mold of the hippocampus of 22 post-infarction depression patients and 29 healthy controls were obtained and compared through auto-segmentation and vertex analysis technology.Results:Volume compari-son showed no statistical difference of the bilateral hippocampus volumes between the two groups (left P= 0.09,right P=0 .3 6 ).But shape analysis showed that atrophy of the local hippocampus area was found in the patients'group compared with the health group,mainly in the ventral part of the left hippocampus.Conclusion:The hippocampus of PSD patients has shape changes that may not be found with conventional volume measurement.The study of hippocampus shape may contrib-ute to the early diagnosis and differential diagnosis,and searching the potential connections between diseases.