放射学实践
放射學實踐
방사학실천
RADIOLOGIC PRACTICE
2014年
5期
482-486
,共5页
景国东%汪剑%陈录广%杨波%王莉%陆建平
景國東%汪劍%陳錄廣%楊波%王莉%陸建平
경국동%왕검%진록엄%양파%왕리%륙건평
前列腺肿瘤%前列腺增生%磁共振成像%诊断,鉴别
前列腺腫瘤%前列腺增生%磁共振成像%診斷,鑒彆
전렬선종류%전렬선증생%자공진성상%진단,감별
Prostate neoplasms%Prostatic hyperplasia%Magnetic resonance imaging%Diagnosis,differential
目的：通过动态增强 MRI（DCE-MRI）对前列腺癌进行定量分析，评估DCE-MRI在前列腺癌中的诊断价值。方法：选取46名前列腺疾病患者，年龄43～81岁，包括前列腺癌患者35名，前列腺增生患者11名。所有患者均行常规MRI及DCE-MRI检查，在灌注参数图上测量前列腺癌与正常组织的容积转运常数（Ktrans ）、速率常数（Kep ）、血管外细胞外容积分数（Ve ）值，比较三者在前列腺癌及正常组织中的差异，并进行ROC曲线分析，计算Ktrans、Kep、Ve 诊断前列腺癌的敏感度及特异度并对Ktrans、Kep、Ve 三者与Gleason评分进行相关性分析。结果：在前列腺癌与正常组织中，Ktrans、Kep差异均有统计学意义（P＜0．001），Ve 差异无统计学意义（P＞0．05）。Ktrans、Kep的ROC 曲线下面积最大，两者的诊断敏感度及特异度分别为94．6％、92．9％和85．7％、71．4％。Ve 在前列腺癌诊断中无明显价值。Ktrans、Kep、Ve 与Gleason评分无明显相关性。结论：DCE-MRI定量分析在前列腺癌诊断中具有较高价值，可用于前列腺良恶性病变的鉴别诊断。
目的：通過動態增彊 MRI（DCE-MRI）對前列腺癌進行定量分析，評估DCE-MRI在前列腺癌中的診斷價值。方法：選取46名前列腺疾病患者，年齡43～81歲，包括前列腺癌患者35名，前列腺增生患者11名。所有患者均行常規MRI及DCE-MRI檢查，在灌註參數圖上測量前列腺癌與正常組織的容積轉運常數（Ktrans ）、速率常數（Kep ）、血管外細胞外容積分數（Ve ）值，比較三者在前列腺癌及正常組織中的差異，併進行ROC麯線分析，計算Ktrans、Kep、Ve 診斷前列腺癌的敏感度及特異度併對Ktrans、Kep、Ve 三者與Gleason評分進行相關性分析。結果：在前列腺癌與正常組織中，Ktrans、Kep差異均有統計學意義（P＜0．001），Ve 差異無統計學意義（P＞0．05）。Ktrans、Kep的ROC 麯線下麵積最大，兩者的診斷敏感度及特異度分彆為94．6％、92．9％和85．7％、71．4％。Ve 在前列腺癌診斷中無明顯價值。Ktrans、Kep、Ve 與Gleason評分無明顯相關性。結論：DCE-MRI定量分析在前列腺癌診斷中具有較高價值，可用于前列腺良噁性病變的鑒彆診斷。
목적：통과동태증강 MRI（DCE-MRI）대전렬선암진행정량분석，평고DCE-MRI재전렬선암중적진단개치。방법：선취46명전렬선질병환자，년령43～81세，포괄전렬선암환자35명，전렬선증생환자11명。소유환자균행상규MRI급DCE-MRI검사，재관주삼수도상측량전렬선암여정상조직적용적전운상수（Ktrans ）、속솔상수（Kep ）、혈관외세포외용적분수（Ve ）치，비교삼자재전렬선암급정상조직중적차이，병진행ROC곡선분석，계산Ktrans、Kep、Ve 진단전렬선암적민감도급특이도병대Ktrans、Kep、Ve 삼자여Gleason평분진행상관성분석。결과：재전렬선암여정상조직중，Ktrans、Kep차이균유통계학의의（P＜0．001），Ve 차이무통계학의의（P＞0．05）。Ktrans、Kep적ROC 곡선하면적최대，량자적진단민감도급특이도분별위94．6％、92．9％화85．7％、71．4％。Ve 재전렬선암진단중무명현개치。Ktrans、Kep、Ve 여Gleason평분무명현상관성。결론：DCE-MRI정량분석재전렬선암진단중구유교고개치，가용우전렬선량악성병변적감별진단。
Objective:To assess the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI)in prostate canc-er with the quantitative analysis of prostate cancer by DCE-MRI.Methods:Forty-six patients with prostate diseases,aged between 43 and 81,including 35 patients with prostate cancer and 11 with prostate hyperplasia were selected.All the pa-tients were conducted with conventional MRI and DCE-MRI scan.The variations of the value of Ktrans ,Kep ,and Ve between the prostate cancer and normal tissues were measured and compared.And under the ROC curve analysis,we calculated the sensitivity and specificity of Ktrans ,Kep and Ve in the diagnosis of prostate cancer,as well as the correlation between Ktrans , Kep ,Ve and the Gleason score in prostate cancer.Results:The values of both Ktrans and Kep were significantly different be-tween the prostate cancer and normal tissues,while Ve was not.The areas of Ktrans、Kep under the ROC curve were the lar-gest,and the sensitivity and specificity of both parameters were 94.6%、92.9% vs 85.7%、71.4% ,yet,Ve was clinically useless in the diagnosis of prostate cancer.Meanwhile,Ktrans ,Kep and Ve values were not relevant with Gleason score.Con-clusion:DCE-MRI quantitative analysis plays a significant role in the diagnosis of prostate cancer,and may help in differenti-al diagnosis of prostate tumors.
