CAJ | 학술논문

目的：探讨基于流动敏感交替反转恢复标记技术（FAIR）结合单次激发快速自旋回波（SSFSE）成像技术的动脉自旋标记（ASL）序列无创定量测量前列腺血流灌注（PBF）的可行性。方法：15例经临床活检确诊的前列腺癌患者纳入本组研究，每例患者同时采集4个不同反转时间（1000、1200，1400和1600 ms）下的ASL数据，以获得最优的标记血流到前列腺时间来估算其PBF。结果：前列腺正常组织区域测得的 PBF 为（52．04±8．69）ml／min／100g，前列腺癌区测得的PBF为（79．28±28．89）ml／min／100g，两者差异有统计学意义（P＜0．01，最优TI），表明前列腺癌区有更大的血流灌注。结论：初步结果表明基于流动敏感交替反转恢复标记技术结合单次激发快速自旋回波成像技术的动脉自旋标记序列（FAIR-SSFSE-ASL）可以无创、定量测量前列腺血流灌注，可探测到由于前列腺癌而引起的血流灌注改变。
목적：탐토기우류동민감교체반전회복표기기술（FAIR）결합단차격발쾌속자선회파（SSFSE）성상기술적동맥자선표기（ASL）서렬무창정량측량전렬선혈류관주（PBF）적가행성。방법：15례경림상활검학진적전렬선암환자납입본조연구，매례환자동시채집4개불동반전시간（1000、1200，1400화1600 ms）하적ASL수거，이획득최우적표기혈류도전렬선시간래고산기PBF。결과：전렬선정상조직구역측득적 PBF 위（52．04±8．69）ml／min／100g，전렬선암구측득적PBF위（79．28±28．89）ml／min／100g，량자차이유통계학의의（P＜0．01，최우TI），표명전렬선암구유경대적혈류관주。결론：초보결과표명기우류동민감교체반전회복표기기술결합단차격발쾌속자선회파성상기술적동맥자선표기서렬（FAIR-SSFSE-ASL）가이무창、정량측량전렬선혈류관주，가탐측도유우전렬선암이인기적혈류관주개변。
Objective:The purpose of this study was to demonstrate the feasibility of arterial spin labeling (ASL)se-quence for non-invasive quantitative measurements of prostate blood flow (PBF)in prostate cancer.Methods:Whether the measurement of PBF by FAIR-SSFSE-ASL can reflect prostate blood flow changes induced by prostate cancer in 1 5 prostate cancer subjects (confirmed by biopsy)with a mean age of 70.9 years was evaluated.Moreover,different levels of inversion times (TI= 1000,1200,1400 and 1600ms)were utilized to obtain the optimal time of the inflow of labeled blood into pros-tate on the estimation of PBF.Results:The estimated PBF was (52.04±8.69)ml/min/100g in the prostate normal region, and significant increase of PBF in the prostate cancer region was (79.28±28.89)ml/min/100g (P<0.01 at optimal TI), reflecting an increase of blood flow in the prostate cancer region.Conclusion:In summary,we have demonstrated that non-in-vasive quantitative measurement prostate blood flow can be obtained using an FAIR-SSFSE-ASL sequence.The measure-ment can reflect the expected prostate perfusion changes induced by prostate cancer.