动物医学进展
動物醫學進展
동물의학진전
PROGRESS IN VETERINARY MEDICINE
2014年
5期
114-116
,共3页
钙蛋白酶Ⅰ%心房颤动%结构重构%细胞凋亡
鈣蛋白酶Ⅰ%心房顫動%結構重構%細胞凋亡
개단백매Ⅰ%심방전동%결구중구%세포조망
calpain-Ⅰ%atrial fibrillation%structural remodeling%apoptosis
心房颤动是临床常见的心律失常,能致使血栓栓塞、心功能下降和心律失常性心肌疾病,给人类健康带来极大危害。Ca2+超载是导致心房颤动发病的重要机制之一,钙蛋白酶Ⅰ(calpain-Ⅰ)是一种由 Ca2+激活的蛋白水解酶,对心血管系统产生广泛的生物学效应。研究表明,在心房颤动发生过程中,calpain-Ⅰ活化后会降解心肌收缩蛋白、参与心房肌结构重构和促进细胞凋亡等。因此,calpain-Ⅰ有望成为治疗房颤的新靶点。论文简要阐述了 calpain-Ⅰ与心房颤动的关系。
心房顫動是臨床常見的心律失常,能緻使血栓栓塞、心功能下降和心律失常性心肌疾病,給人類健康帶來極大危害。Ca2+超載是導緻心房顫動髮病的重要機製之一,鈣蛋白酶Ⅰ(calpain-Ⅰ)是一種由 Ca2+激活的蛋白水解酶,對心血管繫統產生廣汎的生物學效應。研究錶明,在心房顫動髮生過程中,calpain-Ⅰ活化後會降解心肌收縮蛋白、參與心房肌結構重構和促進細胞凋亡等。因此,calpain-Ⅰ有望成為治療房顫的新靶點。論文簡要闡述瞭 calpain-Ⅰ與心房顫動的關繫。
심방전동시림상상견적심률실상,능치사혈전전새、심공능하강화심률실상성심기질병,급인류건강대래겁대위해。Ca2+초재시도치심방전동발병적중요궤제지일,개단백매Ⅰ(calpain-Ⅰ)시일충유 Ca2+격활적단백수해매,대심혈관계통산생엄범적생물학효응。연구표명,재심방전동발생과정중,calpain-Ⅰ활화후회강해심기수축단백、삼여심방기결구중구화촉진세포조망등。인차,calpain-Ⅰ유망성위치료방전적신파점。논문간요천술료 calpain-Ⅰ여심방전동적관계。
Atrial fibrillation(AF)is the most prevalent cardiac arrhymia,which severely damages the health of pa-tients by causing stroke,decreasing heart function and developing myocardial disease.Ca2+ overloading is an im-portant mechanism in the pathogenesis of AF,calpain-Ⅰis Ca2+-activated protease,which play many kinds of bio-logical effects in the cardiovascular system.Recent studies have shown that activated calpain-Ⅰmay be a new target for the treatment of AF,involved in atrial structural remodeling,promote myocardial apoptosis in AF,and may be a new target for the treatment of AF.The relationship between calpain-Ⅰand AF were briefly reviewed in this arti-cle.