CAJ | 학술논문

为研究制备盐酸沃尼妙林软膏剂及其体外透皮释药性和抗金黄色葡菌球菌感染的效果，采用乳化法分别制备 W/O 型和 O/W 型盐酸沃尼妙林软膏剂，并用高效液相色谱法测定2种软膏剂中盐酸沃尼妙林体外透皮释药率。制备的 W/O 型和 O/W 型盐酸沃尼妙林软膏剂质量均稳定，W/O 型和 O/W 型盐酸沃尼妙林软膏剂10 h的体外透皮释药率分别为30％±0．42％和18．45％±0．69％；W/O 型与 O/W 型盐酸沃尼妙林软膏剂对金黄色葡萄球菌引起的小鼠皮下感染均有治疗效果，但 W/O 型软膏剂治疗效果更显著。
위연구제비염산옥니묘림연고제급기체외투피석약성화항금황색포균구균감염적효과，채용유화법분별제비 W/O 형화 O/W 형염산옥니묘림연고제，병용고효액상색보법측정2충연고제중염산옥니묘림체외투피석약솔。제비적 W/O 형화 O/W 형염산옥니묘림연고제질량균은정，W/O 형화 O/W 형염산옥니묘림연고제10 h적체외투피석약솔분별위30％±0．42％화18．45％±0．69％；W/O 형여 O/W 형염산옥니묘림연고제대금황색포도구균인기적소서피하감염균유치료효과，단 W/O 형연고제치료효과경현저。
To study transdermal drug release ration of valnemulin hydrochloride ointments invitro and the resistant-ce to S.aureus infection,two kinds of valnemulin hydrochloride ointments,W/O and O/W,were prepared by u-sing emulsification method,the percutaneous permeability ration was determined by HPLC.Two types of valne-mulin hydrochloride ointments showed good stability;the percutaneous penetration rates of W/O and O/W oint-ments were 30%±0.42% and 18.45%±0.69% after 10 hours,respectively.Two types of valnemulin hydro-chloride ointments also showed good treatment results for subcutaneous infections caused by S.aureus in mice,but the W/O ointment shown better result than the O/W formulation.